Evidence map›Paper›PMID 37108994›Full record

ArticleJournal of personalized medicine2023

Breast Density Evaluation According to BI-RADS 5th Edition on Digital Breast Tomosynthesis: AI Automated Assessment Versus Human Visual Assessment.

Daniele Ugo Tari, Rosalinda Santonastaso, Davide Raffaele De Lucia, Marika Santarsiere, Fabio Pinto

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  10. Contrast-enhanced mammography in high-dense breasts: a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Daniele Ugo TariDepartment of Diagnostic Senology District 12, Palazzo della Salute, Caserta Local Health Authority, 81100 Caserta, Italy.ORCID 0000-0002-7312-419X
Rosalinda SantonastasoDepartment of Economics, University of Campania "L. Vanvitelli", 81043 Capua, Italy.ORCID 0000-0002-3639-0683
Davide Raffaele De LuciaDepartment of Diagnostic Senology District 12, Palazzo della Salute, Caserta Local Health Authority, 81100 Caserta, Italy.ORCID 0000-0002-5059-4615
Marika SantarsiereDepartment of Diagnostic Senology District 12, Palazzo della Salute, Caserta Local Health Authority, 81100 Caserta, Italy.
Fabio PintoDepartment of Radiology, "A. Guerriero" Hospital, Caserta Local Health Authority, 81025 Marcianise, Italy.
Regional Health · USGetra (Italy) · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe assessment of breast density is one of the main goals of radiologists because the masking effect of dense fibroglandular tissue may affect the mammographic identification of lesions. The BI-RADS 5th Edition has revised the mammographic breast density categories, focusing on a qualitative evaluation rather than a quantitative one. Our purpose is to compare the concordance of the automatic classification of breast density with the visual assessment according to the latest available classification.

methodsA sample of 1075 digital breast tomosynthesis images from women aged between 40 and 86 years (58 ± 7.1) was retrospectively analyzed by three independent readers according to the BI-RADS 5th Edition. Automated breast density assessment was performed on digital breast tomosynthesis images with the Quantra software version 2.2.3. Interobserver agreement was assessed with kappa statistics. The distributions of breast density categories were compared and correlated with age.

resultsThe agreement on breast density categories was substantial to almost perfect between radiologists (κ = 0.63-0.83), moderate to substantial between radiologists and the Quantra software (κ = 0.44-0.78), and the consensus of radiologists and the Quantra software (κ = 0.60-0.77). Comparing the assessment for dense and non-dense breasts, the agreement was almost perfect in the screening age range without a statistically significant difference between concordant and discordant cases when compared by age.

conclusionsThe categorization proposed by the Quantra software has shown a good agreement with the radiological evaluations, even though it did not completely reflect the visual assessment. Thus, clinical decisions regarding supplemental screening should be based on the radiologist's perceived masking effect rather than the data produced exclusively by the Quantra software.

Indexed as

artificial intelligenceautomated volumetric breast density softwarebreast cancerbreast densitydigital breast tomosynthesismachine learningmammographyQuantrascreeningvisual assessment

Identifiers

PMID37108994
PMCPMC10146726
OpenAlexW4362472448

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.