Evidence map›Paper›PMID 37108962›Full record

ArticleJournal of personalized medicine2023

Susceptibility to Colorectal Cancer Based on HSD17B4 rs721673 and rs721675 Polymorphisms and Alcohol Intake among Taiwan Biobank Participants: A Retrospective Case Control Study Using the Nationwide Claims Data.

Tzu-Chiao Lin, Min-Hua Chuang, Chia-Ni Hsiung, Pi-Kai Chang, Chien-An Sun, Tsan Yang, Yu-Ching Chou, Je-Ming Hu, Chih-Hsiung Hsu

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Tzu-Chiao LinSchool of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
Min-Hua ChuangSchool of Public Health, National Defense Medical Center, Taipei 114, Taiwan.
Chia-Ni HsiungInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu 300, Taiwan.
Pi-Kai ChangDivision of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Chien-An SunDepartment of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan.ORCID 0000-0001-9041-0537
Tsan YangDepartment of Health Business Administration, Meiho University, Pingtung County 912, Taiwan.
Yu-Ching ChouSchool of Public Health, National Defense Medical Center, Taipei 114, Taiwan.ORCID 0000-0003-4823-6541
Je-Ming HuSchool of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
Chih-Hsiung HsuSchool of Public Health, National Defense Medical Center, Taipei 114, Taiwan.ORCID 0000-0003-4423-4231
Tri-Service General Hospital · TWNational Defense Medical Center · TWFu Jen Catholic University · TWMeiho University · TWNational Tsing Hua University · TWTaoyuan Armed Forces General Hospital · TW

Funding

Tri-Service General Hospital TSGH-E-110211Tri-Service General Hospital TSGH-E-111192Tri-Service General Hospital TSGH-E-111194
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a major public health issue, and there are limited studies on the association between 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) polymorphism and CRC. We used two national databases from Taiwan to examine whether HSD17B4 rs721673, rs721675, and alcohol intake were independently and interactively correlated with CRC development. We linked the Taiwan Biobank (TWB) participants' health and lifestyle information and genotypic data from 2012 to 2018 to the National Health Insurance Database (NHIRD) to confirm their medical records. We performed a genome-wide association study (GWAS) using data from 145 new incident CRC cases and matched 1316 healthy, non-CRC individuals. We calculated the odds ratios (OR) and 95% confidence intervals (CI) for CRC based on multiple logistic regression analyses.

Indexed as

alcohol consumptionbiobankcolorectal cancerCRC developmentCRC riskGWASmedical claims datasetpolymorphismretrospective case control study

Identifiers

PMID37108962
PMCPMC10146027
OpenAlexW4360850943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.