Evidence map›Paper›PMID 37108803›Full record

ArticleInternational journal of molecular sciences2023

Proteomic Profiling of Mouse Brain Pyruvate Kinase Binding Proteins: A Hint for Moonlighting Functions of PKM1?

Olga Buneeva, Arthur Kopylov, Oksana Gnedenko, Marina Medvedeva, Alexander Veselovsky, Alexis Ivanov, Victor Zgoda, Alexei Medvedev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Olga BuneevaInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.
Arthur KopylovInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.ORCID 0000-0002-7199-372X
Oksana GnedenkoInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.
Marina MedvedevaDepartment of Biochemistry, School of Biology, Moscow State University, Moscow 119991, Russia.
Alexander VeselovskyInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.ORCID 0000-0001-6362-7757
Alexis IvanovInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.ORCID 0000-0002-7022-6748
Victor ZgodaInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.ORCID 0000-0002-4532-4274
Alexei MedvedevInstitute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia.
Institute of Biomedical Chemistry · RULomonosov Moscow State University · RU

Funding

Program for Basic Research in the Russian Federation for a long-term period (2021-2030) 122030100170-5
6 · The paper itself

Abstract

Affinity-based proteomic profiling is widely used for the identification of proteins involved in the formation of various interactomes. Since protein-protein interactions (PPIs) reflect the role of particular proteins in the cell, identification of interaction partners for a protein of interest can reveal its function. The latter is especially important for the characterization of multifunctional proteins, which can play different roles in the cell. Pyruvate kinase (PK), a classical glycolytic enzyme catalyzing the last step of glycolysis, exists in four isoforms: PKM1, PKM2, PKL, and PKR. The enzyme isoform expressed in actively dividing cells, PKM2, exhibits many moonlighting (noncanonical) functions. In contrast to PKM2,

Indexed as

Carrier ProteinsPyruvate KinaseAnimalsBrainGlycolysisLigandsMiceProtein IsoformsProteomicsCarrier ProteinsLigandsProtein IsoformsPyruvate Kinaseinteractomemoonlighting functionsPKMPKM binding proteinspyruvate kinasepyruvate kinase isoforms

Identifiers

PMID37108803
PMCPMC10143413
OpenAlexW4366771309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.