Evidence map›Paper›PMID 37108784›Full record

ArticleInternational journal of molecular sciences2023

APC Loss Prevents Doxorubicin-Induced Cell Death by Increasing Drug Efflux and a Chemoresistant Cell Population in Breast Cancer.

Casey D Stefanski, Anne Arnason, Sara Maloney, Janna Kotsen, Elizabeth Powers, Jian-Ting Zhang, Jenifer R Prosperi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Casey D StefanskiDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Anne ArnasonDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0001-6464-7418
Sara MaloneyHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA.
Janna KotsenDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Elizabeth PowersDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0009-0002-5943-6864
Jian-Ting ZhangDepartment of Cell and Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USA.
Jenifer R ProsperiDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
University of Notre Dame · USUniversity of Toledo · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
NCATS NIH HHS UL1 TR001108NIH HHS UL1 TR001108
6 · The paper itself

Abstract

Chemoresistance is a major health concern affecting cancer patients. Resistance is multifactorial, with one mechanism being the increased expression of ABC transporters (such as MDR1 and MRP1), which are drug efflux transporters capable of preventing intracellular accumulation of drugs and cell death. Our lab showed that the loss of

Indexed as

Adenomatous Polyposis ColiBreast NeoplasmsAnimalsATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersCell DeathCell Line, TumorDoxorubicinDrug Resistance, NeoplasmFemaleHumansMiceATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersDoxorubicinABC transportersAdenomatous Polyposis Colibreast cancerchemoresistancedoxorubicinSTAT3tumor initiating cells

Identifiers

PMID37108784
PMCPMC10145529
OpenAlexW4366771808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.