Evidence map›Paper›PMID 37108682›Full record

ArticleInternational journal of molecular sciences2023

Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H

Kenneth R Olson, Kasey J Clear, Yan Gao, Zhilin Ma, Nathaniel M Cieplik, Alyssa R Fiume, Dominic J Gaziano, Stephen M Kasko, Jennifer Luu, Ella Pfaff and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Reaction Mechanisms of HAntioxidants (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Kenneth R OlsonIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-0178-2203
Kasey J ClearDepartment of Chemistry and Biochemistry, Indiana University South Bend, South Bend, IN 46615, USA.ORCID 0000-0001-8628-681X
Yan GaoIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Zhilin MaIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-2493-0889
Nathaniel M CieplikIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.ORCID 0000-0002-4354-2358
Alyssa R FiumeIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Dominic J GazianoIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Stephen M KaskoIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Jennifer LuuIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Ella PfaffIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Anthony TravlosIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Cecilia VelanderIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Katherine J WilsonIndiana University School of Medicine-South Bend, South Bend, IN 46617, USA.
Elizabeth D EdwardsDepartment of Chemistry and Biochemistry, Indiana University South Bend, South Bend, IN 46615, USA.
Karl D StraubCentral Arkansas Veteran's Healthcare System, Little Rock, AR 72205, USA.
Gang WuDepartment of Internal Medicine, The University of Texas-McGovern Medical School, Houston, TX 77030, USA.ORCID 0000-0001-6803-0853
University of Notre Dame · USIndiana University South Bend · USCentral Arkansas Veterans Healthcare System · USThe University of Texas Health Science Center at Houston · US

Funding

Novel Carbon Nanozyme Mechanisms for Traumatic Brain InjuryR01NS094535 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HEGDE, MURALIDHAR L, KENT, THOMAS · 2015 to 2024
$4.1M
National Institute of Health Grant NO R01NS094535 (TAK, PJD)NINDS NIH HHS R01 NS094535
6 · The paper itself

Abstract

Naphthoquinone (1,4-NQ) and its derivatives (NQs, juglone, plumbagin, 2-methoxy-1,4-NQ, and menadione) have a variety of therapeutic applications, many of which are attributed to redox cycling and the production of reactive oxygen species (ROS). We previously demonstrated that NQs also oxidize hydrogen sulfide (H

Indexed as

Hydrogen SulfideNaphthoquinonesCysteineGlutathioneOxidation-ReductionOxygenProteinsSulfhydryl CompoundsThiosulfatesCysteineGlutathioneHydrogen SulfideNaphthoquinonesOxygenProteinsSulfhydryl CompoundsThiosulfatesantioxidantsnaphthoquinonesnaphthoquinone thiol adductsreactive oxygen speciesreactive sulfur species

Identifiers

PMID37108682
PMCPMC10138938
OpenAlexW4366549145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.