Evidence map›Paper›PMID 37108642›Full record

ReviewInternational journal of molecular sciences2023

Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies.

Xuan-Thanh-An Nguyen, Lude Moekotte, Astrid S Plomp, Arthur A Bergen, Maria M van Genderen, Camiel J F Boon

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  6. The efficacy and safety of oral and topical carbonic anhydrase inhibitors for the treatment of macular edema secondary to retinitis pigmentosa: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xuan-Thanh-An NguyenDepartment of Ophthalmology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-8350-5896
Lude MoekotteDepartment of Ophthalmology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-5159-4262
Astrid S PlompDepartment of Clinical Genetics, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-4903-8232
Arthur A BergenDepartment of Clinical Genetics, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Maria M van GenderenDepartment of Ophthalmology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Camiel J F BoonDepartment of Ophthalmology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Amsterdam University Medical Centers · NLLeiden University Medical Center · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized by the degeneration of rod photoreceptors, followed by the degeneration of cone photoreceptors. As a result of photoreceptor degeneration, affected individuals experience gradual loss of visual function, with primary symptoms of progressive nyctalopia, constricted visual fields and, ultimately, central vision loss. The onset, severity and clinical course of RP shows great variability and unpredictability, with most patients already experiencing some degree of visual disability in childhood. While RP is currently untreatable for the majority of patients, significant efforts have been made in the development of genetic therapies, which offer new hope for treatment for patients affected by inherited retinal dystrophies. In this exciting era of emerging gene therapies, it remains imperative to continue supporting patients with RP using all available options to manage their condition. Patients with RP experience a wide variety of physical, mental and social-emotional difficulties during their lifetime, of which some require timely intervention. This review aims to familiarize readers with clinical management options that are currently available for patients with RP.

Indexed as

Night BlindnessRetinal DystrophiesRetinitis PigmentosaHumansRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor Cellsclinical managementgene therapygenetic counselinggeneticslow visionlow-vision rehabilitationretinitis pigmentosa

Identifiers

PMID37108642
PMCPMC10139437
OpenAlexW4366392627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.