Evidence map›Paper›PMID 37108498›Full record

ArticleInternational journal of molecular sciences2023

Novel Functionalized Spiro [Indoline-3,5'-pyrroline]-2,2'dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential.

Mohd Asif, Sahir Sultan Alvi, Tazeen Azaz, Abdul Rahman Khan, Bhoopendra Tiwari, Bilal Bin Hafeez, Malik Nasibullah

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Exploring the Therapeutic Potential ofMolecules (Basel, Switzerland) · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mohd AsifDepartment of Chemistry, Integral University, Lucknow 226026, Uttar Pradesh, India.ORCID 0000-0002-8787-192X
Sahir Sultan AlviDepartment of Immunology and Microbiology, South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.ORCID 0000-0002-5650-748X
Tazeen AzazDepartment of Biological and Synthetic Chemistry, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.ORCID 0000-0002-6656-7339
Abdul Rahman KhanDepartment of Chemistry, Integral University, Lucknow 226026, Uttar Pradesh, India.
Bhoopendra TiwariDepartment of Biological and Synthetic Chemistry, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.ORCID 0000-0002-4187-3313
Bilal Bin HafeezDepartment of Immunology and Microbiology, South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Malik NasibullahDepartment of Chemistry, Integral University, Lucknow 226026, Uttar Pradesh, India.
Integral University · INSanjay Gandhi Post Graduate Institute of Medical Sciences · INThe University of Texas Rio Grande Valley · US

Funding

Targeting ribosome biogenesis and desmoplastic tumor microenvironment for the treatment of advanced pancreatic cancerSC1GM140982 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI HAFEEZ, BILAL BIN · 2021 to 2024
$1.5M
NIGMS NIH HHS SC1 GM140982
6 · The paper itself

Abstract

A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs) (

Indexed as

Antineoplastic AgentsErbB ReceptorsHumansIndolesMolecular Docking SimulationMolecular StructurePyrrolesReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsErbB ReceptorsIndolesindolinePyrrolespyrrolineReactive Oxygen SpeciesADMET studiesand anticancer effectscancer cellsdrug-likenessisatin-derived spirooxindoles (SOXs)ROS generation

Identifiers

PMID37108498
PMCPMC10139052
OpenAlexW4366090591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.