Evidence map›Paper›PMID 37108424›Full record

ArticleInternational journal of molecular sciences2023

Reorganization and Suppression of Store-Operated Calcium Entry in Podocytes of Type 2 Diabetic Rats.

Konstantin Gusev, Alexey Shalygin, Dmitrii Kolesnikov, Leonid Shuyskiy, Sofia Makeenok, Lyubov Glushankova, Konstantin Sivak, Kirill Yakovlev, Yana Orshanskaya, Guanghui Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024
    Review
  3. Non-voltage-gated CaAmerican journal of physiology. Renal physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Konstantin GusevInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Alexey ShalyginInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Dmitrii KolesnikovInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Leonid ShuyskiyInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Sofia MakeenokInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Lyubov GlushankovaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Konstantin SivakSmorodintsev Research Institute of Influenza WHO National Influenza Centre of Russia, St. Petersburg 197376, Russia.ORCID 0000-0003-4064-5033
Kirill YakovlevSmorodintsev Research Institute of Influenza WHO National Influenza Centre of Russia, St. Petersburg 197376, Russia.ORCID 0000-0001-7000-3467
Yana OrshanskayaSmorodintsev Research Institute of Influenza WHO National Influenza Centre of Russia, St. Petersburg 197376, Russia.
Guanghui WangDepartment of Pharmacology, College of Pharmaceutic Sciences, Soochow University, Suzhou 215031, China.
Andrey BakhtyukovSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.ORCID 0000-0002-2060-2020
Kira DerkachSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.ORCID 0000-0001-6555-9540
Alexander ShpakovSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.ORCID 0000-0002-4293-3162
Elena KaznacheyevaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0000-0003-1273-1188
Institute of Cytology · RUInstitute of Evolutionary Physiology and Biochemistry · RUResearch Institute of Influenza · RUSoochow University · CN

Funding

National Natural Science Foundation of China 32261133525Russian Scientific Foundation 22-24-00761Russian Scientific Foundation 23-44-00054
6 · The paper itself

Abstract

Type 2 diabetes mellitus (DM2) is a widespread metabolic disorder that results in podocyte damage and diabetic nephropathy. Previous studies demonstrated that TRPC6 channels play a pivotal role in podocyte function and their dysregulation is associated with development of different kidney diseases including nephropathy. Here, using single channel patch clamp technique, we demonstrated that non-selective cationic TRPC6 channels are sensitive to the Ca

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diabetic NephropathiesPodocytesAnimalsCalciumCalcium ChannelsHumansMaleRatsTRPC6 Cation ChannelTRPC Cation ChannelsCalciumCalcium ChannelsTRPC6 Cation ChannelTRPC Cation Channelsdiabetic nephropathyORAI channelssodium–calcium exchanger (NCX)store-operated calcium entry (SOCE)TRPC6 channelstype 2 diabetes mellitus

Identifiers

PMID37108424
PMCPMC10139047
OpenAlexW4365513859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.