Evidence map›Paper›PMID 37108413›Full record

ArticleInternational journal of molecular sciences2023

Critical Role of the Presynaptic Protein CAST in Maintaining the Photoreceptor Ribbon Synapse Triad.

Akari Hagiwara, Ayako Mizutani, Saki Kawamura, Manabu Abe, Yamato Hida, Kenji Sakimura, Toshihisa Ohtsuka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Akari HagiwaraDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan.ORCID 0000-0001-6470-6641
Ayako MizutaniDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan.
Saki KawamuraDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan.
Manabu AbeDepartment of Animal Model Development, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Yamato HidaDepartment of Biochemistry, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Kenji SakimuraDepartment of Animal Model Development, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Toshihisa OhtsukaDepartment of Biochemistry, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Tokyo University of Science · JPNiigata University · JPUniversity of Yamanashi · JP

Funding

Japan Science and Technology Agency CREST JPMJCR1751Japan Society for the Promotion of Science 20K09769Japan Society for the Promotion of Science 22H02717The Takeda Science Foundation K21-085
6 · The paper itself

Abstract

The cytomatrix at the active zone-associated structural protein (CAST) and its homologue, named ELKS, being rich in glutamate (E), leucine (L), lysine (K), and serine (S), belong to a family of proteins that organize presynaptic active zones at nerve terminals. These proteins interact with other active zone proteins, including RIMs, Munc13s, Bassoon, and the β subunit of Ca

Indexed as

Nerve Tissue ProteinsSynapsesPhotoreceptor CellsPresynaptic TerminalsRetinaSynaptic TransmissionNerve Tissue ProteinsCASTELKShorizontal cellphotoreceptorretinaribbon synapse

Identifiers

PMID37108413
PMCPMC10138387
OpenAlexW4365514904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.