Evidence map›Paper›PMID 37108275›Full record

ArticleInternational journal of molecular sciences2023

Deficiency of AP1 Complex

Luca Mignani, Nicola Facchinello, Marco Varinelli, Elena Massardi, Natascia Tiso, Cosetta Ravelli, Stefania Mitola, Peter Schu, Eugenio Monti, Dario Finazzi and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Luca MignaniDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.ORCID 0000-0002-9958-1225
Nicola FacchinelloNeuroscience Institute, Italian Research Council (CNR), 35131 Padova, Italy.ORCID 0000-0003-4898-4064
Marco VarinelliIstituto di Ricerche Farmacologiche Mario Negri IRCCS, 24126 Bergamo, Italy.ORCID 0000-0001-9046-9555
Elena MassardiDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.
Natascia TisoDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID 0000-0002-5444-9853
Cosetta RavelliDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.ORCID 0000-0002-3554-6711
Stefania MitolaDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.ORCID 0000-0002-5557-738X
Peter SchuDepartment of Cellular Biochemistry, University Medical Center, Georg-August University, Humboldtallee 23, 37073 Gottingen, Germany.ORCID 0000-0001-7169-1097
Eugenio MontiDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.
Dario FinazziDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.ORCID 0000-0001-5176-2839
Giuseppe BorsaniDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.
Daniela ZizioliDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123 Brescia, Italy.
University of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITMario Negri Institute for Pharmacological Research · ITNeuroscience Institute · ITUniversity of Göttingen · DEUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously expressed and are composed of four different subunits: γ, β1, μ1 and σ1. Two different complexes are present in eukaryotic cells, AP1G1 (contains γ1 subunit) and AP1G2 (contains γ2 subunit); both are indispensable for development. One additional tissue-specific isoform exists for μ1A, the polarized epithelial cells specific to μ1B; two additional tissue-specific isoforms exist for σ1A: σ1B and σ1C. Both AP1 complexes fulfil specific functions at the

Indexed as

Neurodevelopmental DisordersTranscription Factor AP-1ZebrafishZebrafish ProteinsAnimalsEndosomesEpithelial CellsFemaleHumansMaleMiceProtein Isoformstrans-Golgi NetworkProtein IsoformsTranscription Factor AP-1Zebrafish ProteinsadaptinopathiesCRISPR/Cas9 techniqueembryonic developmentintracellular vesicular trafficking

Identifiers

PMID37108275
PMCPMC10138411
OpenAlexW4365146626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.