Evidence map›Paper›PMID 37108258›Full record

ArticleInternational journal of molecular sciences2023

Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.

Kuo-Hsuan Chang, Chia-Hsin Liu, Yi-Ru Wang, Yen-Shi Lo, Chun-Wei Chang, Hsiu-Chuan Wu, Chiung-Mei Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0003-4972-9823
Chia-Hsin LiuDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Yi-Ru WangDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Yen-Shi LoDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chun-Wei ChangDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-5265-1978
Hsiu-Chuan WuDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-8526-9161
Chiung-Mei ChenDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-0769-0353
Chang Gung University · TW

Funding

Linkou Chang Gung Memorial Hospital CMRPG3M144, CMRPG3M216
6 · The paper itself

Abstract

Increased oxidative stress and neuroinflammation play a crucial role in the pathogenesis of Parkinson's disease (PD). In this study, the expression levels of 52 genes related to oxidative stress and inflammation were measured in peripheral blood mononuclear cells of the discovery cohort including 48 PD patients and 25 healthy controls. Four genes, including

Indexed as

Apoptotic Protease-Activating Factor 1Macrophage Colony-Stimulating FactorParkinson DiseaseCognitive DysfunctionHumansLeukocytes, MononuclearMental Status and Dementia TestsReceptor Protein-Tyrosine KinasesReceptors, Colony-Stimulating FactorUp-RegulationAPAF1 protein, humanApoptotic Protease-Activating Factor 1CSF1 protein, humanMacrophage Colony-Stimulating FactorReceptor Protein-Tyrosine KinasesReceptors, Colony-Stimulating FactorAPAF1CSF1Roxidative stress

Identifiers

PMID37108258
PMCPMC10139006
OpenAlexW4365147029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.