Evidence map›Paper›PMID 37108241›Full record

ArticleInternational journal of molecular sciences2023

PDGF Receptors and Signaling Are Required for 3D-Structure Formation and Differentiation of Human iPSC-Derived Hepatic Spheroids.

Syusaku Tsuzuki, Tomoyuki Yamaguchi, Takashi Okumura, Toshiharu Kasai, Yasuharu Ueno, Hideki Taniguchi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Syusaku TsuzukiDivision of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-0071, Japan.
Tomoyuki YamaguchiLaboratory of Regenerative Medicine, Tokyo University of Pharmacy and Life Science, Tokyo 192-0392, Japan.
Takashi OkumuraDivision of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-0071, Japan.
Toshiharu KasaiDivision of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-0071, Japan.
Yasuharu UenoDivision of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-0071, Japan.
Hideki TaniguchiDivision of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-0071, Japan.
The University of Tokyo · JPTokyo University of Pharmacy and Life Sciences · JP

Funding

Grants-in-Aid for Scientific Research (KAKENHI) 18KK0252Grants-in-Aid for Scientific Research (KAKENHI) 20K08952Grants-in-Aid for Scientific Research (KAKENHI) 21H04830Japan Agency for Medical Research and Development 19lm0203005h9903Japan Agency for Medical Research and Development 21fk0310103h0505Japan Agency for Medical Research and Development 22bk0104102h0003Japan Agency for Medical Research and Development 22bm0304002h0310Japan Agency for Medical Research and Development 22bm1004003h0003Japan Agency for Medical Research and Development 22fk0210073s0503
6 · The paper itself

Abstract

Human iPSC-derived liver organoids (LO) or hepatic spheroids (HS) have attracted widespread interest, and the numerous studies on them have recently provided various production protocols. However, the mechanism by which the 3D structures of LO and HS are formed from the 2D-cultured cells and the mechanism of the LO and HS maturation remain largely unknown. In this study, we demonstrate that

Indexed as

Induced Pluripotent Stem CellsAnimalsCell Culture TechniquesCell DifferentiationHepatocytesHumansLiverMiceReceptor, Platelet-Derived Growth Factor alphaSpheroids, CellularReceptor, Platelet-Derived Growth Factor alpha3D culturehepatic spheroidshuman iPSCliver organoidsPDGF receptorsplatelet-derived growth factors (PDGFs)

Identifiers

PMID37108241
PMCPMC10138705
OpenAlexW4365146833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.