Evidence map›Paper›PMID 37108163›Full record

ArticleInternational journal of molecular sciences2023

RFRP-3 Influences Apoptosis and Steroidogenesis of Yak Cumulus Cells and Compromises Oocyte Meiotic Maturation and Subsequent Developmental Competence.

Xianrong Xiong, Yulei Hu, Bangting Pan, Yanjin Zhu, Xixi Fei, Qinhui Yang, Yumian Xie, Yan Xiong, Daoliang Lan, Wei Fu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xianrong XiongKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.ORCID 0000-0002-5470-122X
Yulei HuKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Bangting PanKey Laboratory for Animal Science of National Ethnic Affairs Commission, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Yanjin ZhuKey Laboratory for Animal Science of National Ethnic Affairs Commission, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Xixi FeiKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Qinhui YangKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Yumian XieKey Laboratory for Animal Science of National Ethnic Affairs Commission, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Yan XiongKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Daoliang LanKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Wei FuKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Jian LiKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
State Ethnic Affairs Commission · CNSouthwest Minzu University · CN

Funding

the Key Research and Development Program of Sichuan Provincial Science and Technology Program 23ZDYF3118the Southwest Minzu University Double World-Class Project XM2023008the Special Project of Sichuan Beef Cattle Innovation Team of National Agricultural Industrial Technology System SCCXTD-2022-13
6 · The paper itself

Abstract

RF amide-related peptide 3 (RFRP-3), a mammalian ortholog of gonadotropin-inhibitory hormone (GnIH), is identified to be a novel inhibitory endogenous neurohormonal peptide that regulates mammalian reproduction by binding with specific G protein-coupled receptors (GPRs) in various species. Herein, our objectives were to explore the biological functions of exogenous RFRP-3 on the apoptosis and steroidogenesis of yak cumulus cells (CCs) and the developmental potential of yak oocytes. The spatiotemporal expression pattern and localization of GnIH/RFRP-3 and its receptor GPR147 were determined in follicles and CCs. The effects of RFRP-3 on the proliferation and apoptosis of yak CCs were initially estimated by EdU assay and TUNEL staining. We confirmed that high-dose (10

Indexed as

Cumulus CellsOocytesAnimalsApoptosisCattleFemaleGonadotropinsMammalsGonadotropinsapoptosiscumulus celldevelopmentRFRP-3steroidogenesis

Identifiers

PMID37108163
PMCPMC10138887
OpenAlexW4363675789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.