Evidence map›Paper›PMID 37108077›Full record

ArticleInternational journal of molecular sciences2023

Efficacy of Immunization against a Novel Synthetic 13-Amino Acid Betaglycan-Binding Peptide Sequence of Inhibin α Subunit on Promoting Fertility in Female Rats.

Xingfa Han, Xue Xia, Weihao Chen, Fengyan Meng, Xiaohan Cao, Guixian Bu, Tian Gan, Xiaogang Du, Qiuxia Liang, Xianyin Zeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xingfa HanIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Xue XiaIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Weihao ChenIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.ORCID 0000-0001-5520-3380
Fengyan MengIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Xiaohan CaoIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Guixian BuIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.ORCID 0000-0001-6700-1292
Tian GanIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Xiaogang DuIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Qiuxia LiangIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Xianyin ZengIsotope Research Lab, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
Sichuan Agricultural University · CN

Funding

Natural Science Foundation of Sichuan Province 2022NSFSC0753Natural Science Foundation of Sichuan Province 2023NSFSC0240
6 · The paper itself

Abstract

Inhibins suppress the FSH production in pituitary gonadotrope cells by robustly antagonizing activin signaling by competitively binding to activin type II receptors (ACTR II). The binding of inhibin A to ACTR II requires the presence of its co-receptor, namely, betaglycan. In humans, the critical binding site for betaglycan to inhibin A was identified on the inhibin α subunit. Through conservation analysis, we found that a core 13-amino-acid peptide sequence <VRTTSDGGYSFKY> within the betaglycan-binding epitope on human inhibin α subunit is highly conserved across species. Based on the tandem sequence of such a conserved 13-amino-acid betaglycan-binding epitope (INHα13AA-T), we developed a novel inhibin vaccine and tested its efficacy in promoting female fertility using the female rat as a model. Compared with placebo-immunized controls, INHα13AA-T immunization induced a marked (

Indexed as

ActivinsInhibinsActivin ReceptorsAmino AcidsAnimalsFemaleFertilityFollicle Stimulating HormoneHumansImmunizationMammalsPeptidesProteoglycansRatsReceptors, Transforming Growth Factor betaVaccinationActivin ReceptorsActivinsAmino AcidsbetaglycanFollicle Stimulating Hormoneinhibin-alpha subunitInhibinsPeptidesProteoglycansReceptors, Transforming Growth Factor betafertilityfolliculogenesisinhibinovulationratvaccine

Identifiers

PMID37108077
PMCPMC10138769
OpenAlexW4363679380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.