Evidence map›Paper›PMID 37108070›Full record

ArticleInternational journal of molecular sciences2023

A Pilot Study to Evaluate Genipin in

Marcela Huertas-Bello, Jerson Andrés Cuéllar-Sáenz, Cristian Nicolas Rodriguez, Jesús Alfredo Cortés-Vecino, Myriam Lucia Navarrete, Marcel Yecid Avila, Elena Koudouna

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Non-antibiotic management of bacterial keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Marcela Huertas-BelloDepartment of Ophthalmology, Faculty of Medicine, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.ORCID 0000-0003-1099-3184
Jerson Andrés Cuéllar-SáenzGrupo de Investigación Parasitología Veterinaria, Department of Animal Health, Faculty of Veterinary Medicine and Zootechnics, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.ORCID 0000-0003-2257-8981
Cristian Nicolas RodriguezDepartment of Microbiology, Faculty of Medicine, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Jesús Alfredo Cortés-VecinoGrupo de Investigación Parasitología Veterinaria, Department of Animal Health, Faculty of Veterinary Medicine and Zootechnics, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.ORCID 0000-0003-2641-604X
Myriam Lucia NavarreteDepartment of Microbiology, Faculty of Medicine, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Marcel Yecid AvilaDepartment of Ophthalmology, Faculty of Medicine, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Elena KoudounaDepartment of Ophthalmology, Faculty of Medicine, Bogota DC, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Universidad Nacional de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious keratitis is a vision-threatening microbial infection. The increasing antimicrobial resistance and the fact that severe cases often evolve into corneal perforation necessitate the development of alternative therapeutics for effective medical management. Genipin, a natural crosslinker, was recently shown to exert antimicrobial effects in an ex vivo model of microbial keratitis, highlighting its potential to serve as a novel treatment for infectious keratitis. This study aimed to evaluate the antimicrobial and anti-inflammatory effects of genipin in an in vivo model of

Indexed as

KeratitisPseudomonas InfectionsAnimalsCorneaCytokinesHumansIridoidsMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Inbred C57BLPilot ProjectsPseudomonas aeruginosaStaphylococcus aureusCytokinesgenipinIridoidsMatrix Metalloproteinase 2Matrix Metalloproteinase 9anti-inflammatorybacterial keratitiscorneal collagen crosslinkingcorneal crosslinking in infectious keratitisgenipininfectious keratitismatrix metalloproteinasespro-inflammatory cytokines

Identifiers

PMID37108070
PMCPMC10138382
OpenAlexW4363648084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.