Evidence map›Paper›PMID 37108065›Full record

ArticleInternational journal of molecular sciences2023

Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant Pathogens.

Walaa K Mousa, Rose Ghemrawi, Tareq Abu-Izneid, Azza Ramadan, Farah Al-Marzooq

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Walaa K MousaCollege of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.
Rose GhemrawiCollege of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.ORCID 0000-0002-2465-0812
Tareq Abu-IzneidCollege of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.
Azza RamadanCollege of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.
Farah Al-MarzooqDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, UAE University, Al Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0001-5711-6264
Al Ain University · AEMansoura University · EGUnited Arab Emirates University · AE

Funding

Al Ain University Ph2022-3-100
6 · The paper itself

Abstract

The human body is a superorganism that harbors trillions of microbes, most of which inhabit the gut. To colonize our bodies, these microbes have evolved strategies to regulate the immune system and maintain intestinal immune homeostasis by secreting chemical mediators. There is much interest in deciphering these chemicals and furthering their development as novel therapeutics. In this work, we present a combined experimental and computational approach to identifying functional immunomodulatory molecules from the gut microbiome. Based on this approach, we report the discovery of lactomodulin, a unique peptide from

Indexed as

Methicillin-Resistant Staphylococcus aureusMicrobiotaAnti-Bacterial AgentsAnti-Inflammatory AgentsHumansMicrobial Sensitivity TestsPeptidesAnti-Bacterial AgentsAnti-Inflammatory AgentsPeptidesantibioticsanti-inflammatoryimmunomodulatoryLactobacillusmicrobiome

Identifiers

PMID37108065
PMCPMC10138793
OpenAlexW4363648155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.