Evidence map›Paper›PMID 37107652›Full record

ArticleGenes2023

Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico.

Julyann Perez-Mayoral, Maria Gonzalez-Pons, Hilmaris Centeno-Girona, Ingrid M Montes-Rodríguez, Marievelisse Soto-Salgado, Belisa Suárez, Natalia Rodríguez, Giancarlo Colón, Javier Sevilla, Daphne Jorge and 10 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 2 countries.

Julyann Perez-MayoralNCI Center for Cancer Genomics, Bethesda, MD 20892, USA.
Maria Gonzalez-PonsUniversity of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.ORCID 0000-0002-3694-0534
Hilmaris Centeno-GironaUniversity of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.
Ingrid M Montes-RodríguezUniversity of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.
Marievelisse Soto-SalgadoUniversity of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.
Belisa SuárezUniversity of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.
Natalia RodríguezSchool of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Giancarlo ColónSchool of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Javier SevillaSchool of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Daphne JorgeSchool of Medicine, Ponce Health Sciences University, Ponce, PR 00716, USA.
Xavier LlorDepartment of Internal Medicine and Digestive Diseases, School of Medicine, Yale University, New Haven, CT 06520, USA.
Rosa M XicolaDepartment of Internal Medicine and Digestive Diseases, School of Medicine, Yale University, New Haven, CT 06520, USA.
Doris H ToroVA Caribbean Healthcare System, San Juan, PR 00921, USA.ORCID 0000-0001-7580-5100
Luis Tous-LópezAshford Presbyterian Community Hospital, San Juan, PR 00907, USA.
Marla Torres-TorresAshford Presbyterian Community Hospital, San Juan, PR 00907, USA.
José S ReyesAshford Presbyterian Community Hospital, San Juan, PR 00907, USA.
Nicolas López-AcevedoAshford Presbyterian Community Hospital, San Juan, PR 00907, USA.
Ajay GoelBeckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0003-1396-6341
Segundo Rodríguez-QuilichiniDepartment of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00935, USA.
Marcia Cruz-CorreaUniversity of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.
University of Puerto Rico System · PRTexas Health Dallas · USCentral University of the Caribbean · PRUniversity of Puerto Rico, Medical Sciences Campus · PRYale University · USCenter for Cancer Research · USCity of Hope · USPonce Health Sciences University · PRVA Caribbean Healthcare System · PR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
UPR/MDACC Partnership for Excellence in Cancer Research(Parent Grant U54 CA096297)U54CA096297 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SHARON Hermes GIORDANO, REYNOLD Eugenio LOPEZ-ENRIQUEZ · 2002 to 2026
$36.9M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BONILLA-FELIX, MELVIN · 2020 to 2024
$17.7M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Clinicopathology of IGF2 loss of imprinting in colon neoplasiaK22CA115913 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CRUZ-CORREA, MARCIA ROXANA · 2007 to 2009
$621k
Human Papilloma Virus Infection in Patients with Colorectal CancerR21CA167220 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CRUZ-CORREA, MARCIA ROXANA · 2012 to 2013
$404k
Familial Colorectal Cancer Registry in Puerto Rico: A Feasibility StudyR03CA130034 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CRUZ-CORREA, MARCIA ROXANA · 2007 to 2009
$188k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K22 CA115913NCI NIH HHS R03 CA130034NCI NIH HHS R21 CA167220NCI NIH HHS U54 CA096297NIGMS NIH HHS U54 GM133807NIMHD NIH HHS G12 MD007600
6 · The paper itself

Abstract

backgroundThe incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico. CRC is currently the leading cause of cancer death among Hispanic men and women living in Puerto Rico (PRH). The objective of this study was to characterize the molecular markers and clinicopathologic features of colorectal tumors from PRH to better understand the molecular pathways leading to CRC in this Hispanic subpopulation.

methodsMicrosatellite instability (MSI), CpG island methylator phenotype (CIMP), and

resultsOf the 718 tumors analyzed, 34.2% (

conclusionsThe differences observed in the prevalence of the molecular markers among PRH tumors compared to other racial/ethnic groups suggest a distinct molecular carcinogenic pathway among Hispanics. Additional studies are warranted.

Indexed as

Colorectal NeoplasmsProto-Oncogene Proteins B-rafBiomarkersDNA MethylationFemaleHispanic or LatinoHumansMaleMicrosatellite InstabilityProto-Oncogene Proteins p21(ras)Puerto RicoBiomarkersProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)colorectal cancerearly-onset colorectal cancerHispanicsmolecular markers

Identifiers

PMID37107652
PMCPMC10138302
OpenAlexW4365146587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.