Evidence map›Paper›PMID 37107603›Full record

ArticleGenes2023

Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity.

Huda Adwan Shekhidem, Lital Sharvit, Derek M Huffman, Irena Manov, Gil Atzmon, Imad Shams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Splice Variant ofGenes · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Huda Adwan ShekhidemInstitute of Evolution, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0002-4766-9751
Lital SharvitDepartment of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0002-2577-1907
Derek M HuffmanDepartments of Molecular Pharmacology, Medicine, and the Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-2292-3717
Irena ManovInstitute of Evolution, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0001-8523-0849
Gil AtzmonDepartment of Human Biology, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0001-6895-3607
Imad ShamsInstitute of Evolution, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0001-6496-2928
University of Haifa · ILAlbert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere shortening or loss of shelterin components activates DNA damage response (DDR) pathways, leading to a replicative senescence that is usually coupled with a senescence-associated secretory phenotype (SASP). Recent studies suggested that telomere aberration that activates DDR may occur, irrespective of telomere length or loss of shelterin complex. The blind mole-rat (

Indexed as

SpalaxTelomeraseAnimalsLongevityMole RatsShelterin ComplexTelomereTelomere ShorteningShelterin ComplexTelomeraseDNA damagesenescenceshelterinSpalaxtelomerase activitytelomere length

Identifiers

PMID37107603
PMCPMC10137574
OpenAlexW4362465384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.