Evidence map›Paper›PMID 37107556›Full record

ArticleGenes2023

Adaptively Integrative Association between Multivariate Phenotypes and Transcriptomic Data for Complex Diseases.

Yujia Li, Yusi Fang, Hung-Ching Chang, Michael Gorczyca, Peng Liu, George C Tseng

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yujia LiEli Lilly and Company, Indianapolis, IN 46225, USA.
Yusi FangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Hung-Ching ChangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-4847-2547
Michael GorczycaDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Peng LiuDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4012-3884
George C TsengDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
University of Pittsburgh · USEli Lilly (United States) · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Power calculation and design issues in next-generation sequencingR01CA190766 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TSENG, GEORGE C. · 2015 to 2018
$876k
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
Congruence of mouse model to human in transcriptomic responseR21LM012752 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TSENG, GEORGE C. · 2018 to 2019
$370k
NCATS NIH HHS UL1 TR001857NCI NIH HHS R01 CA190766NIH HHS S10 OD028483NLM NIH HHS R21 LM012752
6 · The paper itself

Abstract

Phenotype-gene association studies can uncover disease mechanisms for translational research. Association with multiple phenotypes or clinical variables in complex diseases has the advantage of increasing statistical power and offering a holistic view. Existing multi-variate association methods mostly focus on SNP-based genetic associations. In this paper, we extend and evaluate two adaptive Fisher's methods, namely AFp and AFz, from the

Indexed as

alpha-FetoproteinsTranscriptomeGene Expression ProfilingGenetic Association StudiesPhenotypealpha-Fetoproteinsassociation analysiscomplex diseasegene expressionphenotypes

Identifiers

PMID37107556
PMCPMC10138055
OpenAlexW4361007631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.