Evidence map›Paper›PMID 37107276›Full record

ReviewAntioxidants (Basel, Switzerland)2023

Oxidative Stress, Inflammation and Colorectal Cancer: An Overview.

Annamária Bardelčíková, Jindřich Šoltys, Ján Mojžiš

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 5 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 5 syntheses or guidelines pooled it, 178 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Trial
  7. Article
  8. Investigation of the Protective Effect ofInternational journal of molecular sciences · 2026
    Article
  9. Food science & nutrition · 2026
    Review
  10. Observational
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Annamária BardelčíkováDepartment of Pharmacology, Medical Faculty of University of Pavol Jozef Šafárik in Košice, Tr. SNP 1, 040 11 Košice, Slovakia.
Jindřich ŠoltysInstitute of Parasitology, Slovak Academy of Science, Hlinkova 3, 040 01 Košice, Slovakia.ORCID 0000-0002-4490-3151
Ján MojžišDepartment of Pharmacology, Medical Faculty of University of Pavol Jozef Šafárik in Košice, Tr. SNP 1, 040 11 Košice, Slovakia.ORCID 0000-0002-7974-4525
University of Pavol Jozef Šafárik · SKInstitute of Parasitology of the Slovak Academy of Sciences · SK

Funding

Operational Programme Integrated Infrastructure, funded by the ERDF ITMS2014+: 313011V455
6 · The paper itself

Abstract

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in the initiation and development of CRC. Although OS plays a vital part in the life of all organisms, its long-term effects on the human body may be involved in the development of different chronic diseases, including cancer diseases. Chronic OS can lead to the oxidation of biomolecules (nucleic acids, lipids and proteins) or the activation of inflammatory signaling pathways, resulting in the activation of several transcription factors or the dysregulation of gene and protein expression followed by tumor initiation or cancer cell survival. In addition, it is well known that chronic intestinal diseases such as inflammatory bowel disease (IBD) are associated with an increased risk of cancer, and a link between OS and IBD initiation and progression has been reported. This review focuses on the role of oxidative stress as a causative agent of inflammation in colorectal cancer.

Indexed as

colorectal carcinomainflammationinflammatory bowel diseaseoxidative stress

Identifiers

PMID37107276
PMCPMC10135609
OpenAlexW4363647790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.