ReviewAntioxidants (Basel, Switzerland)2023
Antioxidant Supplementation on Male Fertility-A Systematic Review.
Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06339996 (To Investigate Supplements for Improving Male Sperm Quality and Combating Aging), which is not on this map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
To Investigate Supplements for Improving Male Sperm Quality and Combating Aging
Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials.The world journal of men's health · 2026Article
- Oxidative Stress and Male Infertility: A Critical Analysis of Current Diagnostic and Therapeutic Methods.Antioxidants (Basel, Switzerland) · 2026Review
- The link between diabetes and male infertility: mechanisms and implications.Scientific reports · 2026Article
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- The critical role of oxidative stress in male infertility: causes, diagnostic biomarkers, and the efficacy of antioxidant therapy.Molecular biology reports · 2026Review
- Epidemiology, Etiopathogenesis, Diagnosis, and Treatment of Male Infertility-Current Trends and Future Directions: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Sixty-day oral antioxidant supplementation enhances sperm morphology and seminal plasma antioxidant capacity in stallions.Journal of animal science · 2026Article
- Treatment Options for Improving The Semen Quality in Obese Men: A Scoping Review.Journal of multidisciplinary healthcare · 2026Review
- Evaluating the Impact of Folate on Male Infertility Using Mendelian Randomization: A Comprehensive Analysis.The world journal of men's health · 2026Article
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Swadamshtradi rasayana attenuates radiofrequency radiation-induced oxidative stress and improves sperm parameters in Swiss albino mice.Frontiers in reproductive health · 2026Article
- Excess copper exposure and male reproductive toxicity: molecular mechanisms and potential interventions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Regional variations in the morphology of the efferent ductules: a histological perspective in rats, bulls, stallions, and boars.BMC veterinary research · 2025Article
- The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications.Antioxidants (Basel, Switzerland) · 2025Review
- Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis.Biological trace element research · 2025Article
- Changes in L-Carnitine Metabolism Affect the Gut Microbiome and Influence Sexual Behavior Through the Gut-Testis Axis.Microorganisms · 2025Article
- Sperm metabolomic signatures of asthenozoospermia and teratozoospermia in Chinese reproductive-age men.Scientific reports · 2025Article
- Effects of Goji Berry Supplementation on Immune-Related and Antioxidant Gene Expression in the Male Rabbit Reproductive Tract.Animals : an open access journal from MDPI · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to review the current literature regarding the effect of antioxidant supplementation (AS) on male fertility parameters, as AS is commonly used to treat male infertility due to the availability and affordability of antioxidants in many parts of the world. MATERIALS AND
methodsPubMed, Medline, and Cochrane electronic bibliographies were searched using the modified Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines to evaluate studies on the benefit of antioxidant therapy on infertile men. Results were analyzed regarding the following aspects: (a) ingredient and dose; (b) potential mechanism of action and rationale for use; and (c) effect on various reported outcomes.
resultsThus, 29 studies found a substantial positive effect of AS on outcomes of assisted reproductive therapy (ART), WHO semen parameters, and live-birth rate. Carnitines, Vitamin E and C, N-acetyl cysteine, coenzyme Q10, selenium, zinc, folic acid, and lycopene were beneficial ingredients. Nevertheless, some studies did not show a substantial change in one or more factors.
conclusionAS seems to have a positive effect on male fertility. Environmental factors may play an increasing role in fertility. Further studies are needed to determine the optimal AS combination and the influence of environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.