Evidence map›Paper›PMID 37107152›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Using an Antibiogram Profile to Improve Infection Control and Rational Antimicrobial Therapy in an Urban Hospital in The Gambia, Strategies and Lessons for Low- and Middle-Income Countries.

Saffiatou Darboe, Ruel Mirasol, Babapelumi Adejuyigbe, Abdul Khalie Muhammad, Behzad Nadjm, Annabelle De St Maurice, Tiffany L Dogan, Buntung Ceesay, Solomon Umukoro, Uduak Okomo and 5 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Saffiatou DarboeMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.ORCID 0000-0002-4711-3307
Ruel MirasolDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Babapelumi AdejuyigbeDavid Geffen School of Medicine, University of California, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0001-7373-3596
Abdul Khalie MuhammadMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Behzad NadjmMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Annabelle De St MauriceDepartment of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Tiffany L DoganDepartment of Clinical Epidemiology and Infection Prevention, University of California, UCLA Health, Los Angeles, CA 90095, USA.
Buntung CeesayMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Solomon UmukoroMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Uduak OkomoMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Davis NwakanmaMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.ORCID 0000-0002-6706-6069
Anna RocaMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Ousman SeckaMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Karen ForrestMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.ORCID 0000-0002-9484-0830
Omai B GarnerDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
MRC Unit the Gambia · GMUniversity of California, Los Angeles · USUCLA Health · USUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council MC_UU_00031/7
6 · The paper itself

Abstract

Antimicrobial resistance is a global health threat and efforts to mitigate it is warranted, thus the need for local antibiograms to improve stewardship. This study highlights the process that was used to develop an antibiogram to monitor resistance at a secondary-level health facility to aid empirical clinical decision making in a sub-Saharan African county. This retrospective cross-sectional descriptive study used 3 years of cumulative data from January 2016 to December 2018. Phenotypic data was manually imputed into WHONET and the cumulative antibiogram constructed using standardized methodologies according to CLSI M39-A4 guidelines. Pathogens were identified by standard manual microbiological methods and antimicrobial susceptibility testing was performed using Kirby-Bauer disc diffusion method according to CLSI M100 guidelines. A total of 14,776 non-duplicate samples were processed of which 1163 (7.9%) were positive for clinically significant pathogens. Among the 1163 pathogens,

Indexed as

antimicrobial resistance (AMR)bacteraemiacumulative antibiogramEscherichia coli (E. coli)infection prevention and control (IPC)Klebsiella pnuemonaie (K. pneumoniae)low- and middle-income countries (LMICs)Staphylococcus aureus (S. aureus)urinary tract infection (UTI)

Identifiers

PMID37107152
PMCPMC10135392
OpenAlexW4366772113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.