Evidence map›Paper›PMID 37107075›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Linezolid Pharmacokinetics and Its Association with Adverse Drug Reactions in Patients with Drug-Resistant Pulmonary Tuberculosis.

Chandrasekaran Padmapriyadarsini, Rajesh Solanki, S M Jeyakumar, Anuj Bhatnagar, M Muthuvijaylaksmi, Bharathi Jeyadeepa, Devarajulu Reddy, Prashanth Shah, Rathinam Sridhar, Vikram Vohra and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06590428 (Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06590428 narecruitingnot on this mapstarted 2026, after this paper: background citation

Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis

TypeinterventionalSponsorAlbert Einstein College of MedicineRan2026 to 2029Enrolled280ConditionsRifampin-resistant Tuberculosis, Drug-resistant TuberculosisArmsTherapeutic Drug Monitoring for Linezolid
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Chandrasekaran PadmapriyadarsiniICMR-National Institute for Research in Tuberculosis, Chennai 600031, India.ORCID 0000-0002-1324-4595
Rajesh SolankiB.J. Medical College and Hospital, Ahmedabad 380016, India.
S M JeyakumarICMR-National Institute for Research in Tuberculosis, Chennai 600031, India.ORCID 0000-0002-4500-8431
Anuj BhatnagarRajan Babu Institute of Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.
M MuthuvijaylaksmiICMR-National Institute for Research in Tuberculosis, Chennai 600031, India.
Bharathi JeyadeepaICMR-National Institute for Research in Tuberculosis, Chennai 600031, India.
Devarajulu ReddyICMR-National Institute for Research in Tuberculosis, Chennai 600031, India.
Prashanth ShahB.J. Medical College and Hospital, Ahmedabad 380016, India.
Rathinam SridharGovernment Hospital of Thoracic Medicine, Chennai 600047, India.
Vikram VohraNational Institute for Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Namrata Kaur BhuiGrand TB Hospital, Mumbai 400015, India.
National Institute of Research in Tuberculosis · INB.J. Medical College · INBombay Hospital · INGovernment Hospital of Thoracic Medicine · INLRS Institute of Tuberculosis and Respiratory Diseases · IN

Funding

United States Agency for International Development xx
6 · The paper itself

Abstract

We evaluated the relationship between the pharmacokinetic parameters of linezolid (LZD) and development of adverse drug reactions (ADRs) in patients with pulmonary drug-resistant tuberculosis. A prospective cohort of adults with pulmonary multidrug-resistant tuberculosis with additional resistance to fluoroquinolone (MDR-TB

Indexed as

linezolidmyelosuppressionneuropathypharmacokineticstherapeutic drug monitoring

Identifiers

PMID37107075
PMCPMC10135341
OpenAlexW4362668599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.