Tripeptide IRW Improves AMPK/eNOS Signaling Pathway via Activating ACE2 in the Aorta of High-Fat-Diet-Fed C57BL/6 Mice.

Fatemeh Ashkar, Khushwant S Bhullar, Xu Jiang, Jianping Wu

Open access · goldAbstract read

In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Triglyceride-glucose and TyG-BMI indexes predict acute pancreatitis in adult critically ill patients admitted to intensive care.Clinics (Sao Paulo, Brazil) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fatemeh AshkarDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Khushwant S BhullarDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Xu JiangDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Jianping WuDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0003-2574-5191

University of Alberta · CA

Funding

Natural Sciences and Engineering Research Council of Canada CRDPJ 532150-18

6 · The paper itself

Abstract

This study aims to investigate the effect of tripeptide IRW on the local renin-angiotensin system (RAS), particularly angiotensin-converting enzyme 2 (ACE2), and their association with signaling pathways in the aorta of a high-fat-diet (HFD)-induced insulin-resistant mouse model. C57BL/6 mice were fed HFD (45% of the total calories) for six weeks, and then IRW was added to the diet (45 mg/kg body weight (BW)) for another eight weeks. ACE2 mRNA expression and protein level(s) were increased (

Indexed as

ACE2eNOSGLUT4insulin resistanceIRWpeptides

Identifiers

PMID37106756

DOI10.3390/biology12040556

PMCPMC10135585

OpenAlexW4362669146

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.