ReviewBioengineering (Basel, Switzerland)2023
Recent Advances in Apical Periodontitis Treatment: A Narrative Review.
Review in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Application and performance of artificial intelligence-based models in the detection, segmentation and classification of periapical lesions: a systematic review.Frontiers in dental medicine · 2025Pooled it
- Influence of sealer type on treatment outcome of teeth with apical periodontitis: a systematic review.Brazilian dental journalPooled it
- Healing Outcome of Different Aqueous-based Calcium Hydroxide Intracanal Medicament in Patients with Pulpal Necrosis and Symptomatic Apical Periodontitis: A Randomised Controlled Trial.European endodontic journal · 2025Trial
- Synthesis, Characterisation and Antibacterial Activity of Reduced Graphene Oxide-Cuprous Oxide Nanocomposite Against Dual Species Biofilms Using Clsm.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Immunotherapies based on macrophage reprogramming in periodontitis and apical periodontitis.Clinical oral investigations · 2026Review
- Nell-1 inhibits osteoclast differentiation and bone resorption in apical periodontitis.Journal of molecular histology · 2026Article
- Antimicrobial efficacy of chitosan nanoparticles as intracanal medicament againstJournal of conservative dentistry and endodontics · 2026Article
- Article
- Evaluation of contact-active antibacterial properties of cetylpyridinium chloride-graphene oxide coatings on dental restorative and titanium surfaces: an in vitro study.BMC oral health · 2026Article
- Microbial control and a simple regenerative endodontic protocol achieve durable apical healing and long-term root development: A 10-year case report.Journal of clinical and experimental dentistry · 2026Review
- Host Immunogenetic Profile Modulates Susceptibility to Apical Periodontitis in a Colombian Population.Current issues in molecular biology · 2026Article
- Development of Periapical Index Score Classification System in Periapical Radiographs Using Deep Learning.Journal of imaging informatics in medicine · 2025Article
- Effects of Caffeine on Dental Mesenchymal Stem Cells: Implications for Regenerative Applications.Journal of functional biomaterials · 2025Article
- Evaluation of biocompatibility, antimicrobial activity, and immunomodulatory effects of mineral trioxide aggregate modified with zeolite-clinoptilolite as a root-end filling material.BMC oral health · 2025Article
- Evaluation of Vitamin D and of Some Biomarkers of Bone Remodelling (CTX-1, Osteocalcin, BALP) in Subjects with Periapical Inflammatory Cysts: An Observational Study.Journal of clinical medicine · 2025Article
- The Oral Microbiome and Systemic Health: Bridging the Gap Between Dentistry and Medicine.Cureus · 2025Review
- DeepLabv3 + method for detecting and segmenting apical lesions on panoramic radiography.Clinical oral investigations · 2025Article
- Synthesis, physical properties, and root canal sealing of experimental MTA- and salicylate-based root canal sealers.PloS one · 2025Article
- Effect of Simple Oral Dental Extraction on Systemic Serum Amyloid A Concentrations in Horses.Veterinary medicine and science · 2024Article
- Modern Advances in Microendodontics: The State of the Art.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. However, clinical failure has been reported with this approach; thus, alternative procedures are required. This review highlights recent literature regarding advanced approaches for the treatment of apical periodontitis. Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, have been tested to increase the success rate of treatment for apical periodontitis. Some of these approaches remain in the in vivo phase of research, while others have just entered the translational research phase to validate clinical application. However, a detailed understanding of the molecular mechanisms that occur during development of the immunoinflammatory reaction in apical periodontitis remains unclear. The aim of this review was to summarize advanced approaches for the treatment of apical periodontitis. Further research can confirm the potential of these alternative nonsurgical endodontic treatment approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.