ArticleBMC ophthalmology2023
Prevalence and risk factors of keratoconus (including oxidative stress biomarkers) in a cohort study of Shiraz university of medical science employees in Iran.
Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Behavioral and Sociodemographic Factors Associated with Vision-Related Quality of Life in Keratoconus: A Cross-Sectional Study in Riyadh, Saudi Arabia.Vision (Basel, Switzerland) · 2026Article
- Tear cytokine profiles between children with allergic conjunctivitis at varying eye rubbing frequencies and keratoconus: A cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- The Clinical Significance of the Early Screening of Keratoconus and Its Impact on Maintaining Quality of Life.Life (Basel, Switzerland) · 2026Article
- Evaluating corneal topographic patterns in keratoconic eyes and their association with keratoconus changes over time.International journal of ophthalmology · 2026Article
- Health-related quality of life among healthcare workers: a comparative analysis using regression, conditional tree and forests.BMC public health · 2025Article
- Evaluation of systemic inflammatory biomarkers associated with high-density lipoprotein in keratoconus patients: a retrospective case-control study.BMC ophthalmology · 2025Article
- Metabolic syndrome and health-related quality of life: unraveling the role of gender (A SUMS employees cohort-based study).BMC research notes · 2025Article
- Prevalence of Keratoconus and Associated Risk Factors Among High School Students in Couva, Trinidad: A Cross-Sectional Study.Vision (Basel, Switzerland) · 2025Article
- Progression and regression of keratoconus in an Iranian population.Scientific reports · 2025Article
- An optimized multi-scale dilated attention layer for keratoconus disease classification.International ophthalmology · 2025Article
- Omics in Keratoconus: From Molecular to Clinical Practice.Journal of clinical medicine · 2025Review
- Different keratoconus definitions can lead to substantial prevalence disparities in population-based studies.Scientific reports · 2025Article
- Keratoconus.Nature reviews. Disease primers · 2024Article
- Mendelian randomization reveals that abnormal lipid metabolism mediates the causal relationship between body mass index and keratoconus.Scientific reports · 2024Article
- Retinoscopes: Past and present.World journal of methodology · 2024Article
- Exploring the causal relationship between body mass index and keratoconus: a Mendelian randomization study.Frontiers in medicine · 2024Article
- A high body mass index strengthens the association between the time of eye rubbing and keratoconus in a Chinese population: a case control study.BMC public health · 2023Article
- Clinical Profiles of Patients with Keratoconus Visiting a Tertiary Eye Center in Kuala Lumpur, Malaysia.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine the prevalence of keratoconus in Shiraz University of Medical Sciences Employees and the related risk factors including oxidative stress biomarkers.
methods2546 subjects' mean age ± SD, 40.35 ± 6.70 (46% male) were recruited. All participants underwent objective refraction using auto-refractometer and retinoscopy, followed by subjective refraction, and bio-microscopy. Pentacam imaging was performed for the detected keratoconus patients. The prevalence of keratoconus and frequency of the visual impairment among keratoconus cases were evaluated. Potential risk factors of sex, age, family history of keratoconus, body mass index ≥ 30 kg/m
resultsThe prevalence of keratoconus at least in one eye was 0.98% (95% CI: 0.6- 1.4%). The best corrected visual acuity in the keratoconus group was 0.06 ± 0.1 and the rest of the population was 0.01 ± 0.07 logMAR (p < 0.001). The frequency of visual impairment in the keratoconus group was zero. Odds ratios of the family history of keratoconus (21.00, 95% CI: 9.00-48.00, p < 0.001) and LDL ≥ 110 mg/dL (3.00, 95% CI: 1.20-6.40, p = 0.01) were significant.
conclusionsKeratoconus is rare and is not considered a risk factor for visual impairment. A family history of keratoconus and elevated serum LDL levels are contributing risk factors, suggesting an inflammatory background for the disease. Serum levels of LDL ≥ 110 mg/dL in the blood increased the risk of keratoconus three folds.
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