Trial reportBMC anesthesiology2023
Timing of intubation and ICU mortality in COVID-19 patients: a retrospective analysis of 4198 critically ill patients during the first and second waves.
Trial report in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiologic, Clinical Characteristics and Risk Factors of Critical Ill Patients Admitted to the ICU for Severe Acute Respiratory Syndrome Coronavirus 2 Infection (COVID-19)
Metabolomics and Clinical Data to Predict High-Flow Nasal Cannula Failure and Optimize Respiratory Support in Acute Hypoxemic Respiratory Failure
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses.Critical care (London, England) · 2025Pooled it
- The Prevalence of Cardiac Arrhythmias in COVID-19 Patients Undergoing CRRT During the First 24 Hours of ICU Admission.Medical journal of the Islamic Republic of Iran · 2026Article
- Impact of Endotracheal Intubation Timing on Clinical Outcomes in Patients with Severe Pneumonia: A Single-Center Retrospective Cohort Study.Infection and drug resistance · 2026Article
- Factors associated with the intubation of patients with acute respiratory failure and their impact on mortality: a retrospective cohort study.BMC pulmonary medicine · 2025Article
- Elderly patients in crisis: unveiling outcomes and management approaches in severe COVID-19 cases - a retrospective analysis from Brazil.Einstein (Sao Paulo, Brazil) · 2025Article
- Factors associated with mortality in patients with cardiovascular diseases affected by COVID-19: a cross-sectional study.Revista latino-americana de enfermagem · 2025Article
- Time-series metabolomic profiling of SARS-CoV-2 infection: Possible prognostic biomarkers in patients in the ICU by ¹H-NMR analysis.PloS one · 2025Article
- Prediction of prolonged mechanical ventilation in the intensive care unit via machine learning: a COVID-19 perspective.Scientific reports · 2024Article
- Development and external validation of an interpretable machine learning model for the prediction of intubation in the intensive care unit.Scientific reports · 2024Article
- Effect of timing of intubation on clinical outcomes of patients with septic shock: a retrospective cohort study.Scientific reports · 2024Article
- Mortality Impact of Severe COVID-19 in the ICU: A Study from the Târgu Mureș Support Unit.Life (Basel, Switzerland) · 2024Article
- Effect of noninvasive ventilation on mortality and clinical outcomes among patients with severe hypoxemic COVID-19 pneumonia after high-flow nasal oxygen failure: a multicenter retrospective French cohort with propensity score analysis.Respiratory research · 2024Article
- The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome-Lessons Learned?Journal of clinical medicine · 2024Review
- Article
- Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia.Tropical medicine and infectious disease · 2024Article
- [Bacterial coinfection in the critically-ill COVID-19 patient: incidence, impact and need for antimicrobial therapy].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Article
- Use of non-invasive respiratory supports in high-intensity internal medicine setting during the first two waves of the COVID-19 pandemic emergency in Italy: a multicenter, real-life experience.Internal and emergency medicine · 2023Article
- Association between early intubation and mortality in patients at high risk for noninvasive ventilation failure: a propensity-matched cohort study.Therapeutic advances in respiratory diseaseObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal time to intubate patients with SARS-CoV-2 pneumonia has not been adequately determined. While the use of non-invasive respiratory support before invasive mechanical ventilation might cause patient-self-induced lung injury and worsen the prognosis, non-invasive ventilation (NIV) is frequently used to avoid intubation of patients with acute respiratory failure (ARF). We hypothesized that delayed intubation is associated with a high risk of mortality in COVID-19 patients.
methodsThis is a secondary analysis of prospectively collected data from adult patients with ARF due to COVID-19 admitted to 73 intensive care units (ICUs) between February 2020 and March 2021. Intubation was classified according to the timing of intubation. To assess the relationship between early versus late intubation and mortality, we excluded patients with ICU length of stay (LOS) < 7 days to avoid the immortal time bias and we did a propensity score and a cox regression analysis.
resultsWe included 4,198 patients [median age, 63 (54‒71) years; 71% male; median SOFA (Sequential Organ Failure Assessment) score, 4 (3‒7); median APACHE (Acute Physiology and Chronic Health Evaluation) score, 13 (10‒18)], and median PaO
conclusionsEarly intubation within the first 24 h of ICU admission in patients with COVID-19 pneumonia was found to be an independent protective risk factor of mortality.
trial registrationThe study was registered at Clinical-Trials.gov (NCT04948242) (01/07/2021).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.