Evidence map›Paper›PMID 37106222›Full record

ArticleMolecular neurobiology2023

Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area.

Yi Xu, Zheng-Huan Zhu, Xu Xu, Hai-Tao Sun, Hong-Ming Zheng, Jin-Long Zhang, Hong-Hai Wang, Jia-Wei Fang, Ya-Zheng Liu, Lin-Ling Huang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  13. Therapeutic Applications of Stem Cell-Derived Exosomes.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yi XuDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Zheng-Huan ZhuDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Xu XuDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Hai-Tao SunDepartment of Spinal Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Hong-Ming ZhengDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Jin-Long ZhangDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Hong-Hai WangDepartment of Orthopedics, The NO.2 People's Hospital of Fuyang, Fuyang, China.
Jia-Wei FangDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Ya-Zheng LiuDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Lin-Ling HuangNational Engineer Laboratory for Modern Silk, College of Textile and Clothing Engineer, Soochow University, Suzhou, China.
Zhi-Wen SongDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China. realszw@126.com.
Jin-Bo LiuDepartment of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China. czljbljb@126.com.ORCID http://orcid.org/0000-0001-9237-1391
Soochow University · CNFuyang Maternity and Child Health Care Hospital · CNJiangsu University · CN

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81901247Innovative Research Group Project of the National Natural Science Foundation of China 81972048
6 · The paper itself

Abstract

During spinal cord injury (SCI), the homeostasis of the cellular microenvironment in the injured area is seriously disrupted, which makes it extremely difficult for injured neurons with regenerative ability to repair, emphasizing the importance of restoring the cellular microenvironment at the injury site. Neurons interact closely with other nerve cells in the central nervous system (CNS) and regulate these cells. However, the specific mechanisms by which neurons modulate the cellular microenvironment remain unclear. Exosomes were isolated from the primary neurons, and their effects on astrocytes, microglia, oligodendrocyte progenitor cells (OPCs), neurons, and neural stem cells were investigated by quantifying the expression of related proteins and mRNA. A mouse SCI model was established, and neuron-derived exosomes were injected into the mice by the caudal vein to observe the recovery of motor function in mice and the changes in the nerve cells in the lesion area. Neuron-derived exosomes could reverse the activation of microglia and astrocytes and promote the maturation of OPCs in vivo and in vitro. In addition, neuron-derived exosomes promoted neurite outgrowth of neurons and the differentiation of neural stem cells into neurons. Moreover, our experiments showed that neuron-derived exosomes enhanced motor function recovery and nerve regeneration in mice with SCI. Our findings highlight that neuron-derived exosomes could promote the repair of the injured spinal cord by regulating the cellular microenvironment of neurons and could be a promising treatment for spinal cord injury.

Indexed as

ExosomesSpinal Cord InjuriesAnimalsCellular MicroenvironmentMiceNeuronsSpinal CordCellular microenvironmentNerve regenerationNeuron-derived exosomesSpinal cord injury

Identifiers

PMID37106222
OpenAlexW4367172035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.