Evidence map›Paper›PMID 37106168›Full record

ArticleNature medicine2023

CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs.

Li Zhang, Isabel Mosquera, Eric Lucas, Mary Luz Rol, Andre L Carvalho, Partha Basu, CanScreen5 collaborators

2 registry-linked trialsAbstract read
In one paragraph

Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07211204 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Study To Compare The Efficacy Of Cervical Cytology With Molecular Screening In The Detection Of Reactive Cellular Changes In The Cervix In An Open Population

TypeinterventionalSponsorTimser SAPI de CVRan2026 to 2026Enrolled0ConditionsAtypical Squamous Cell of Undetermined Significance, ASC-US, Atypical Glandular Cells of Uncertain Significance, AGUSArmsPhysical examination, Liquid-based cytology, Molecular screening, HPV DNA test, Colposcopy
NCT07480902 narecruitingnot on this mapstarted 2026, after this paper: background citation

Study To Compare The Efficacy Of Cervical Cytology With Molecular Screening For Detecting Reactive Cellular Changes In The Cervix In An Open Population

TypeinterventionalSponsorTimser SAPI de CVRan2026 to 2026Enrolled558ConditionsI) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS), III) Cervical Intraepithelial Neoplasia (CIN), CIN-1, CIN-2, CIN-3, IV) Low-grade Squamous Intraepithelial Lesion (LSIL)ArmsPhysical examination, Liquid-based cytology, Molecular screening, HPV DNA test, Colposcopy
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Determinants of stage at breast cancer diagnosis across different healthcare systems: an international multicentre cohort study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Challenges in the future of cancer screening.International journal of cancer · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Li ZhangInternational Agency for Research on Cancer, Lyon, France.ORCID http://orcid.org/0000-0003-4559-1599
Isabel MosqueraInternational Agency for Research on Cancer, Lyon, France.ORCID http://orcid.org/0000-0001-8886-6244
Eric LucasInternational Agency for Research on Cancer, Lyon, France.ORCID http://orcid.org/0000-0002-1252-1925
Mary Luz RolInternational Agency for Research on Cancer, Lyon, France.ORCID http://orcid.org/0000-0003-4250-092X
Andre L CarvalhoInternational Agency for Research on Cancer, Lyon, France.
Partha BasuInternational Agency for Research on Cancer, Lyon, France. basup@iarc.who.int.ORCID http://orcid.org/0000-0003-0124-4050
CanScreen5 collaborators

Funding

Medical Research CouncilWorld Health Organization 001
6 · The paper itself

Abstract

The CanScreen5 project is a global cancer screening data repository that aims to report the status and performance of breast, cervical and colorectal cancer screening programs using a harmonized set of criteria and indicators. Data collected mainly from the Ministry of Health in each country underwent quality validation and ultimately became publicly available through a Web-based portal. Until September 2022, 84 participating countries reported data for breast (n = 57), cervical (n = 75) or colorectal (n = 51) cancer screening programs in the repository. Substantial heterogeneity was observed regarding program organization and performance. Reported screening coverage ranged from 1.7% (Bangladesh) to 85.5% (England, United Kingdom) for breast cancer, from 2.1% (Côte d'Ivoire) to 86.3% (Sweden) for cervical cancer, and from 0.6% (Hungary) to 64.5% (the Netherlands) for colorectal cancer screening programs. Large variability was observed regarding compliance to further assessment of screening programs and detection rates reported for precancers and cancers. A concern is lack of data to estimate performance indicators across the screening continuum. This underscores the need for programs to incorporate quality assurance protocols supported by robust information systems. Program organization requires improvement in resource-limited settings, where screening is likely to be resource-stratified and tailored to country-specific situations.

Indexed as

Breast NeoplasmsColorectal NeoplasmsUterine Cervical NeoplasmsEarly Detection of CancerFemaleHumansMass Screening

Identifiers

PMID37106168
PMCPMC10202799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.