ArticleNature biomedical engineering2023
A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 140 citations in OpenAlex.
- A soft bioelectronic system with a responsive hydrogel neural interface for direct force quantification and real-time intraoperative craniocerebral injury monitoring.Nature biomedical engineering · 2026Article
- A Geometrically Transient Platform for Bioelectronic Implants.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Mineral-originated bioelectronics for inhibition via lithium electrochemistry.Nature materials · 2026Article
- Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Translational Barriers and AI-Driven Challenges of Microfluidics-Enabled Wearables and Implantable Systems in Personalized Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes.Advanced healthcare materials · 2026Article
- An Event based Body Coupled Transdural Telemetry for Intracortical Brain Computer Interfaces.Communications engineering · 2026Article
- A biomimetic, ultralow-power edge-AI-empowered and self-sustaining gait analysis system.Science advances · 2026Article
- Wearable Electronics for Precision Diagnosis Through Advanced Manufacturing and Integration.Nano-micro letters · 2026Review
- A wireless bioresorbable triboelectric system for postoperative pain control.National science review · 2026Article
- IoT-enabled wireless neural implant for chronic, programmable neuropharmacology and optogenetics.Science advances · 2026Article
- From trade-offs to translation: An interdisciplinary roadmap for neurotechnology.Science advances · 2026Review
- Neural dynamics of temporal interference stimulation monitoring by soft liquid metal interfaces across neural systems.Nature communications · 2026Article
- Active devices and systems for closed-loop neuromodulation.Microsystems & nanoengineering · 2026Review
- Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.Bioactive materials · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Robust magnetoelectric backscatter communication system for bioelectronic implants.Communications engineering · 2026Article
- Microinterventional in-sensor computing system for real-time metabolic health assessment.Nature communications · 2026Article
- An ultrasound-scanning in vivo light source.Nature materials · 2026Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 6 institutions in 3 countries.
Funding
Abstract
Fully implantable wireless systems for the recording and modulation of neural circuits that do not require physical tethers or batteries allow for studies that demand the use of unconstrained and freely behaving animals in isolation or in social groups. Moreover, feedback-control algorithms that can be executed within such devices without the need for remote computing eliminate virtual tethers and any associated latencies. Here we report a wireless and battery-less technology of this type, implanted subdermally along the back of freely moving small animals, for the autonomous recording of electroencephalograms, electromyograms and body temperature, and for closed-loop neuromodulation via optogenetics and pharmacology. The device incorporates a system-on-a-chip with Bluetooth Low Energy for data transmission and a compressed deep-learning module for autonomous operation, that offers neurorecording capabilities matching those of gold-standard wired systems. We also show the use of the implant in studies of sleep-wake regulation and for the programmable closed-loop pharmacological suppression of epileptic seizures via feedback from electroencephalography. The technology can support a broader range of applications in neuroscience and in biomedical research with small animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.