Evidence map›Paper›PMID 37106094›Full record

ReviewNature chemistry2023

Advances in single-molecule junctions as tools for chemical and biochemical analysis.

Essam M Dief, Paul J Low, Ismael Díez-Pérez, Nadim Darwish

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Molecular Rectification: Mechanisms, Modulation Strategies, and Device Realization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. A Material Viewpoint on Metal-Backboned Polymers.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. DNA-Guided Robust Single-Protein Electronic Readout.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Beyond ensemble averages: single-entity approaches for complex systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Review
  13. Origin of Single-Molecule Reaction Chirality.Research (Washington, D.C.) · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Essam M DiefSchool of Molecular and Life Sciences, Curtin University, Bentley, Western Australia, Australia.
Paul J LowSchool of Molecular Sciences, University of Western Australia, Crawley, Western Australia, Australia.ORCID http://orcid.org/0000-0003-1136-2296
Ismael Díez-PérezDepartment of Chemistry, Faculty of Natural & Mathematical Sciences, King's College London, London, UK.
Nadim DarwishSchool of Molecular and Life Sciences, Curtin University, Bentley, Western Australia, Australia. nadim.darwish@curtin.edu.au.ORCID http://orcid.org/0000-0002-6565-1723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of miniaturized electronics has led to the design and construction of powerful experimental platforms capable of measuring electronic properties to the level of single molecules, along with new theoretical concepts to aid in the interpretation of the data. A new area of activity is now emerging concerned with repurposing the tools of molecular electronics for applications in chemical and biological analysis. Single-molecule junction techniques, such as the scanning tunnelling microscope break junction and related single-molecule circuit approaches have a remarkable capacity to transduce chemical information from individual molecules, sampled in real time, to electrical signals. In this Review, we discuss single-molecule junction approaches as emerging analytical tools for the chemical and biological sciences. We demonstrate how these analytical techniques are being extended to systems capable of probing chemical reaction mechanisms. We also examine how molecular junctions enable the detection of RNA, DNA, and traces of proteins in solution with limits of detection at the zeptomole level.

Indexed as

DNANanotechnologyElectronicsProteinsRNADNAProteinsRNA

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.