Evidence map›Paper›PMID 37106090›Full record

ArticlePediatric radiology2023

Association of pancreatic fat on imaging with pediatric metabolic co-morbidities.

Sarah E Swauger, Kaity Fashho, Lindsey N Hornung, Deborah A Elder, Samjhana Thapaliya, Christopher G Anton, Andrew T Trout, Maisam Abu-El-Haija

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah E SwaugerDivision of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Swauger1989@gmail.com.ORCID 0000-0001-7298-4959
Kaity FashhoDivision of Pediatrics, University of Florida College of Medicine, Jacksonville, FL, USA.
Lindsey N HornungDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Deborah A ElderDivision of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Samjhana ThapaliyaDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Christopher G AntonDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Andrew T TroutDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Maisam Abu-El-HaijaDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

backgroundThe relationship between pancreatic fat on imaging and metabolic co-morbidities has not been established in pediatrics. We sought to investigate the relationship between pancreatic fat measured by MRI and endocrine/exocrine dysfunctions along with the metabolic co-morbidities in a cohort of children.

objectiveTo investigate relationships between pancreatic fat quantified by MRI and endocrine and exocrine conditions and metabolic co-morbidities in a cohort of children. MATERIALS AND 

methodsThis was a retrospective review of pediatric patients (n = 187) who had a clinically indicated MRI examination between May 2018 and February 2020. After 51 patients without useable imaging data were excluded, the remaining 136 subjects comprised the study sample. Laboratory studies were assessed if collected within 6 months of MRI and patient charts were reviewed for demographic and clinical information. MRI proton density fat fraction (PDFF) sequence had been acquired according to manufacturer's specified parameters at a slice thickness of 3 mm. Two blinded radiologists independently collected PDFF data.

resultsThe median age at MRI was 12.1 (IQR: 9.0-14.8) years and the majority of patients were Caucasian (79%), followed by African American and Hispanic at 12% and 11% respectively. There was a higher median pancreas fat fraction in patients with exocrine conditions (chronic pancreatitis or exocrine insufficiency) compared to those without (3.5% vs 2.2%, p = 0.03). There was also a higher median fat fraction in the head of pancreas in patients with endocrine insufficient conditions (insulin resistance, pre-diabetes, type 1 and type 2 diabetes) compared to those without endocrine insufficiency when excluding patients with active acute pancreatitis (3.5% vs 2.0%, p = 0.04). Patients with BMI > 85% had higher mean fat fraction compared to patients with BMI ≤ 85% (head: 3.8 vs 2.4%, p = 0.01; body: 3.8 vs 2.5%, p = 0.005; tail: 3.7 vs 2.7%, p = 0.049; overall pancreas fat fraction: 3.8 vs 2.6%, p = 0.002).

conclusionPancreas fat is elevated in patients with BMI > 85% and in those with exocrine and endocrine insufficiencies.

Indexed as

Diabetes Mellitus, Type 2Exocrine Pancreatic InsufficiencyPancreatitisAcute DiseaseChildHumansMagnetic Resonance ImagingMorbidityPancreasEndocrine insufficiencyExocrine insufficiencyMRI proton density fat fractionPancreas fat

Identifiers

PMID37106090
PMCPMC10915690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.