Evidence map›Paper›PMID 37105856›Full record

ReviewTrends in cancer2023

Cellular barcoding tracks heterogeneous clones through selective pressures and phenotypic transitions.

Kennedy K Howland, Amy Brock

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Multiplexed enrichment and tracking of lineages with CloneSweeper.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Single-Cell Lineage Tracing and Clonal State-Fate Analysis.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. Review
  12. Cancer as a Disease of Development Gone Awry.Annual review of pathology · 2024
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kennedy K HowlandDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78734, USA.
Amy BrockDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78734, USA. Electronic address: amy.brock@utexas.edu.
The University of Texas at Austin · US

Funding

Instability of Cancer Cell States in Tumor progression (ICCS)R01CA255536 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI BROCK, AMY, HUANG, SUI · 2021 to 2025
$2.5M
The Allee Effect in Tumor InitiationR01CA226258 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI BROCK, AMY, HUANG, SUI · 2018 to 2022
$2.3M
Using label-free Raman microscopy to predict therapeutic resistance of TNBC cellsU01CA253540 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI BROCK, AMY, YANKEELOV, THOMAS E · 2020 to 2024
$2.1M
A streamlined, high-throughput platform for validation of cancer antigen presentation and isolation of cancer antigen reactive T cellsR33CA256086 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BROCK, AMY, JIANG, NING JENNY · 2021 to 2023
$1.1M
NCI NIH HHS R01 CA226258NCI NIH HHS R01 CA255536NCI NIH HHS R33 CA256086NCI NIH HHS U01 CA253540
6 · The paper itself

Abstract

Genomic DNA barcoding has emerged as a sensitive and flexible tool to measure the fates of clonal subpopulations within a heterogeneous cancer cell population. Coupling cellular barcoding with single-cell transcriptomics permits the longitudinal analysis of molecular mechanisms with detailed clone-level resolution. Numerous recent studies have employed these tools to track clonal cell states in cancer progression and treatment response. With these new technologies comes the opportunity to examine longstanding questions about the origins and contributions of tumor cell heterogeneity and the roles of selection and phenotypic plasticity in disease progression and treatment.

Indexed as

NeoplasmsClone CellsDisease ProgressionHumansbarcodingdrug resistancephenotypic plasticitytumor evolutiontumor heterogeneity

Identifiers

PMID37105856
PMCPMC10339273
OpenAlexW4366977075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.