ReviewInternational dental journal2023
Impact of Clear Aligners on Oral Health and Oral Microbiome During Orthodontic Treatment.
Review in International dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molar-Specific Inflammatory Biomarkers in Adolescents Using Clear Aligners With and Without Attachments
Marginal Biofilm Distribution and Periodontal Response to Supragingival and Juxtagingival Aligner Designs: A Prospective Split-Mouth Clinical Study
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Clear Aligners on the Oral Microbiome: A Systematic Review of Current Evidence.Clinical and experimental dental research · 2026Pooled it
- Plaque removal efficacy of manual versus powered toothbrushes in patients with clear aligners: a single-brushing randomized controlled trial.BMC oral health · 2026Trial
- Impact of Different Cleaning Protocols on the Optical and Morphological Properties of 3D-Printed Aligners After In Vitro Aging.European journal of dentistry · 2026Article
- Effects of clear aligner cleaning agents on Streptococcus mutans biofilms and thermoplastic surface integrity: an in vitro study.Odontology · 2026Article
- Femtosecond laser-induced micro/nanostructures loaded with silver nanoparticles on clear aligners prevent bacterial infection.BMC oral health · 2026Article
- Orthodontic Treatment Need and Short-Term Oral Hygiene Assessment in Children Undergoing Different Early Orthodontic Treatments.Children (Basel, Switzerland) · 2026Article
- Tooth rotational control with varying attachment configurations in clear aligners under compromised periodontal ligament support: a finite element study.BMC oral health · 2026Article
- The Changes of Microbiome Attached on Clear Aligners after Drinking Coca-Cola.Polish journal of microbiology · 2026Article
- Clear Aligner Therapy and Marginal Edge Design: Clinical and Laboratory Evidence on Periodontal and Biological Outcomes-A Scoping Review.Dentistry journal · 2026Review
- [Discussion on the application of clear aligner treatment in multidisciplinary complex cases].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Review
- Accuracy of dentalmonitoring's artificial intelligence in detecting aligner tracking issues: a retrospective multi-centric study.BMC oral health · 2026Article
- The impact of clear aligners therapy on dental caries: a systematic review.Frontiers in dental medicine · 2026Review
- Evaluating the Impact of Clear Dental Aligners on Dental and Periodontal Conditions, Oral Microbial Patterns, and the Immune System.Advances in experimental medicine and biology · 2026Review
- Influence of low viscosity resin infiltrant on the adhesion of orthodontic attachments.Dental press journal of orthodontics · 2026Article
- Anaerobic stress index to predict microbial ecological shifts in clear aligners.Journal of oral microbiology · 2026Article
- Duration-Dependent Caries Risk During Clear Aligner Therapy: A Retrospective Analysis.Biomimetics (Basel, Switzerland) · 2025Article
- In Vitro Evaluation of Biofilm Formation by Oral Microorganisms on Clear Aligner Materials: Influence of Mouthwash Exposure.Journal of functional biomaterials · 2025Article
- 3D Printing of Shape Memory Resin for Orthodontic Aligners with Green Synthesized Antimicrobial ZnO Nanoparticles Coatings: Toward Bioactive Devices.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Comparison of Oral Microbial Profile Among Patients Undergoing Clear Aligner and Fixed Orthodontic Therapies for the Treatment of Malocclusions: An Updated Review.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demand for clear aligners has risen over the past decade because they satisfy patients' desire for less noticeable and more comfortable orthodontic appliances. Because clear aligners are increasingly used in orthodontics, there is a big push to learn more about the physiologic and microbial changes that occur during treatment. The present work highlighted further links between clear aligners and changes in oral health and the oral microbiome and provided plaque control methods for clear aligner trays. Existing literature revealed that clear aligners have no significant influence on the structure of the oral microbiome during orthodontic therapy. Clear aligner treatment demonstrated promising results in terms of controlling plaque index, gingival health, and the prevalence of white spot lesions. Nevertheless, grooves, ridges, microcracks, and abrasions on the aligner surface would provide a prime environment for bacterial adherence and the development of plaque biofilms. A combination of mechanical and chemical methods seems to be a successful approach for removing plaque biofilm from aligners whilst also preventing pigment adsorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.