Evidence map›Paper›PMID 37105705›Full record

ArticleBMJ open2023

Carbon dioxide flushing versus saline flushing of thoracic aortic stents (INTERCEPTevar): protocol for a multicentre pilot randomised controlled trial.

Stephen Crockett, Lydia Hanna, Abhinav Singh, Stephen Gunning, Richard Nicholas, Colin Bicknell, Mohamad Hamady, Dennis Gable, Morad Sallam, Bijan Modarai and 3 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03886675 (Carbon-Dioxide Flushing Versus Saline Flushing in Thoracic Endovascular Aortic Repair to Reduce Neurological Injury), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03886675 naunknown statusnot on this map

Carbon-Dioxide Flushing Versus Saline Flushing in Thoracic Endovascular Aortic Repair to Reduce Neurological Injury: A Pilot Randomised Controlled Trial

TypeinterventionalSponsorImperial College LondonRan2022 to 2024Enrolled120ConditionsStroke, Silent Cerebral Infarction, Neurocognitive Dysfunction, Vascular Brain InjuryArmsCO2 flushing, Saline flushing
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Stephen CrockettDepartment of Surgery and Cancer, Imperial College London, London, UK.ORCID 0000-0003-0772-2615
Lydia HannaDepartment of Surgery and Cancer, Imperial College London, London, UK Lydia.hanna@nhs.net.
Abhinav SinghNeuroradiology Department, Imperial College Healthcare NHS Trust, London, UK.
Stephen GunningClinical Health and Psychology Department, Imperial College Healthcare NHS Trust, London, UK.
Richard NicholasNeurology Department, Imperial College Healthcare NHS Trust, London, UK.
Colin BicknellDepartment of Surgery and Cancer, Imperial College London, London, UK.
Mohamad HamadyImperial Vascular Unit, Imperial College Healthcare NHS Trust, London, UK.
Dennis GableVascular Surgery Department, Baylor Scott & White Health, Dallas, Texas, USA.
Morad SallamVascular Surgery Department, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Bijan ModaraiVascular Surgery Department, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Said AbisiVascular Surgery Department, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Oliver LyonsVascular Surgery Department, Canterbury District Health Board, Christchurch, New Zealand.
Richard GibbsDepartment of Surgery and Cancer, Imperial College London, London, UK.
Imperial College Healthcare NHS Trust · GBSt Thomas' Hospital · GBBaylor Scott & White Health · USCanterbury District Health Board · NZ

Funding

British Heart Foundation FS/17/24/32596
6 · The paper itself

Abstract

introductionThoracic endovascular aortic repair (TEVAR) carries a 3%-6.1% stroke risk, including risk of 'silent' cerebral infarction (SCI). Stent-grafts are manufactured in room air and retain air. Instructions for use recommend saline flushing to 'de-air' the system prior to insertion, but substantial amounts of air are released when deploying them, potentially leading to downstream neuronal injury and SCI. Carbon dioxide (CO METHODS AND ANALYSIS: This is a multicentre pilot RCT, which is taking place in vascular centres in the UK, USA and New Zealand. Patients identified for TEVAR will be enrolled after informed written consent. 120 participants will be randomised (1:1) to TEVAR-CO ETHICS AND DISSEMINATION: The study coordination centre has obtained approval from the London Fulham Research Ethics Committee (19/LO/0836) and Southern Health and Disability Ethics Committee (NZ) and UK's Health Regulator Authority (HRA). The study has received ethical approval for recruitment in the UK (Fulham REC, 19/LO/0836), New Zealand (21/STH/192) and the USA (IRB 019-264, Ref 378630). Consent for entering into the study will be taken using standardised consent forms by the local study team, led by a local PI. The results of the trial will be submitted for publication in an open access journal. TRIAL REGISTRATION NUMBER: NCT03886675.

Indexed as

Carbon DioxideStrokeAorta, ThoracicHumansMulticenter Studies as TopicPilot ProjectsRandomized Controlled Trials as TopicStentsCarbon Dioxidegeriatric medicinestroke medicinevascular medicinevascular surgery

Identifiers

PMID37105705
PMCPMC10151986
OpenAlexW4367320936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.