Evidence map›Paper›PMID 37105694›Full record

ArticleBMJ open2023

Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures.

Teneille Gofton, Sonny Dhanani, Maureen Meade, John Gordon Boyd, Erika Chamberlain, Jennifer Chandler, Michaël Chassé, Nathan B Scales, Yun-Hee Choi, Frédérick D'Aragon and 14 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05306327 (Neurologic Physiology After Removal of Therapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05306327 recruitingnot on this map

Neurologic Physiology After Removal of Therapy (NeuPaRT): Pilot Multicentre Feasibility Study

TypeobservationalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2022 to 2027Enrolled158ConditionsDetermination of DeathArmselectroencephalography (EEG)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. In Reply.Deutsches Arzteblatt international · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 1 country.

Teneille GoftonDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada teneille.gofton@lhsc.on.ca.ORCID 0000-0001-9001-4884
Sonny DhananiPediatric Critical Care, Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
Maureen MeadeCritical Care, McMaster University, Hamilton, Ontario, Canada.
John Gordon BoydDepartments of Neurology and Critical Care, Queen's University, Kingston, Ontario, Canada.
Erika ChamberlainFaculty of Law, Western University, London, Ontario, Canada.
Jennifer ChandlerFaculty of Law, University of Ottawa, Ottawa, Ontario, Canada.
Michaël ChasséDepartment of Medicine, Centre Hospitalier de Montréal, Montréal, Québec, Canada.
Nathan B ScalesDynamical Analysis Laboratory, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Yun-Hee ChoiDepartment of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Frédérick D'AragonDepartment of Anesthesiology, Universite de Sherbrooke Faculte de medecine et des sciences de la sante, Sherbrooke, Quebec, Canada.
Derek DebickiDepartment of Clinical Neurological Sciences, Western University, London, Ontario, Canada.
Shane EnglishClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Tadeu A FantaneanuDepartment of Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Andreas H KramerCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Julie KrommCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Nicholas MurphyPhilosophy and Medicine, Western University, London, Ontario, Canada.ORCID 0000-0003-0137-9238
Loretta NortonDepartment of Psychology, King's University College at Western University, London, Ontario, Canada.
Jeffrey SinghInterdepartmental Division of Critical Care Medicine, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Maxwell J SmithSchool of Health Studies, Faculty of Health Sciences and Rotman Institute of Philosophy, Western University, London, ON, Canada.
Charles WeijerDepartment of Philosophy, Western University, London, Ontario, Canada.ORCID 0000-0002-5510-1074
Sam ShemiePediatric Intensive Care, McGill University, Montreal, Québec, Canada.
Tracey C BentallDepartment of Medicine, London Health Sciences Centre, London, Ontario, Canada.
Eileen CampbellDepartment of Medicine, London Health Sciences Centre, London, Ontario, Canada.
Marat SlessarevDepartment of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Western University · CAUniversity of Ottawa · CALondon Health Sciences Centre · CAOttawa Hospital · CAUniversity of Calgary · CACentre Hospitalier de l’Université de Montréal · CAMcGill University · CAMcMaster University · CAQueen's University · CAUniversité de Sherbrooke · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn donation after circulatory determination of death, death is declared 5 min after circulatory arrest. This practice assumes, but does not explicitly confirm, permanent loss of brain activity. While this assumption is rooted a strong physiological rationale, paucity of direct human data regarding temporal relationship between cessation of brain activity and circulatory arrest during the dying process threatens public and healthcare provider trust in deceased organ donation. METHODS AND ANALYSIS: In this cohort study, we will prospectively record cerebral and brainstem electrical activity, cerebral blood flow velocity and arterial blood pressure using electroencephalography (EEG), brainstem evoked potentials, transcranial doppler and bedside haemodynamic monitors in adult patients undergoing planned withdrawal of life sustaining measures in the intensive care units at five hospital sites for 18 months. We will use MATLAB to synchronise waveform data and compute the time of cessation of each signal relative to circulatory arrest. Our primary outcome is the feasibility of patient accrual, while secondary outcomes are (a) proportion of patients with complete waveform recordings and data transfer to coordinating site and (b) time difference between cessation of neurophysiological signals and circulatory arrest. We expect to accrue 1 patient/site/month for a total of 90 patients. ETHICS AND DISSEMINATION: We have ethics approval from Clinical Trials Ontario (protocol #3862, version 1.0, date 19 January 2022.) and the relevant Research Ethics Board for each site. We will obtain written informed consent from legal substitute decision makers. We will present study results at research conferences including donor family partner forum and in peer-reviewed publications. TRIAL REGISTRATION NUMBER: NCT05306327.

Indexed as

Heart ArrestNeurophysiologyAdultCohort StudiesFeasibility StudiesHumansIntensive Care UnitsMulticenter Studies as TopicObservational Studies as TopicProspective Studiesadult intensive & critical careneurologyneurophysiology

Identifiers

PMID37105694
PMCPMC10152060
OpenAlexW4367293484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.