Evidence map›Paper›PMID 37105682›Full record

Trial reportAJNR. American journal of neuroradiology2023

Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.

C Shah, D Srinivasan, G Erus, M Kurella Tamura, M Habes, J A Detre, W E Haley, A J Lerner, C B Wright, J T Wright and 10 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 1 country.

C ShahFrom the Department of Radiology (C.S.), Imaging Institute, Cleveland Clinic, Cleveland, Ohio shahc2@ccf.org.ORCID 0000-0001-9440-3270
D SrinivasanDepartment of Radiology (D.S., G.E., J.A.D., R.N.B., Y.F., I.M.N.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-7886-9572
G ErusDepartment of Radiology (D.S., G.E., J.A.D., R.N.B., Y.F., I.M.N.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-6633-4861
M Kurella TamuraDivision of Nephrology (M.K.T.), Stanford University, and VA Palo Alto Geriatric Research and Education Clinical Center, Palo Alto, California.ORCID 0000-0001-5227-2479
M HabesBiggs Institute, University of Texas San Antonio (M.H.), San Antonio, Texas.ORCID 0000-0001-9447-5805
J A DetreDepartment of Radiology (D.S., G.E., J.A.D., R.N.B., Y.F., I.M.N.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-8115-6343
W E HaleyDepartment of Nephrology and Hypertension (W.E.H.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-5312-8660
A J LernerDepartments of Neurology (A.J.L.).ORCID 0000-0001-9447-6154
C B WrightNational Institute of Neurological Disorders and Stroke (C.B.W.), National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-9797-6215
J T WrightMedicine (J.T.W.), Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio.ORCID 0000-0003-2557-7239
S OparilDivision of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham, Alabama.ORCID 0000-0002-7505-2599
S B KritchevskySection of Gerontology and Geriatric Medicine, Department of Internal Medicine (S.B.K., J.D.W.), Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0003-3336-6781
H A PunziPunzi Medical Center (H.A.P.), Carrollton, Texas.ORCID 0000-0002-4766-1565
A RastogiDivision of Nephrology (A.R.), Department of Medicine, University of California Los Angeles, Los Angeles, California.ORCID 0000-0002-8117-6010
R MalhotraDivision of Nephrology (R.M.), University of California San Diego, San Diego, California.ORCID 0000-0002-4352-2103
C H StillFrances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, Ohio.ORCID 0000-0002-7106-9246
J D WilliamsonSection of Gerontology and Geriatric Medicine, Department of Internal Medicine (S.B.K., J.D.W.), Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0002-0185-5823
R N BryanDepartment of Radiology (D.S., G.E., J.A.D., R.N.B., Y.F., I.M.N.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-2327-4579
Y FanDepartment of Radiology (D.S., G.E., J.A.D., R.N.B., Y.F., I.M.N.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-9869-4685
I M NasrallahDepartment of Radiology (D.S., G.E., J.A.D., R.N.B., Y.F., I.M.N.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-2346-7562
University of Pennsylvania · USWake Forest University · USAnna Needs Neuroblastoma Answers · USCase Western Reserve University · USCleveland Clinic · USJacksonville College · USNational Institutes of Health · USPalo Alto University · USTexas A&M University – San Antonio · USUniversity Hospitals of Cleveland · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of San Diego · USUniversity of West Georgia · US

Funding

Multiethnic machine learning brain signatures of ADRDR01AG080821 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HABES, MOHAMAD · 2022 to 2025
$2.9M
MIND the KidneysR01DK092241 · NIDDK · STANFORD UNIVERSITY · PI KURELLA TAMURA, MANJULA · 2012 to 2016
$2.8M
NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNIA NIH HHS R01 AG080821NIDDK NIH HHS R01 DK092241
6 · The paper itself

Abstract

background and purposeThe Systolic Blood Pressure Intervention (SPRINT) randomized trial demonstrated that intensive blood pressure management resulted in slower progression of cerebral white matter hyperintensities, compared with standard therapy. We assessed longitudinal changes in brain functional connectivity to determine whether intensive treatment results in less decline in functional connectivity and how changes in brain functional connectivity relate to changes in brain structure. MATERIALS AND

methodsFive hundred forty-eight participants completed longitudinal brain MR imaging, including resting-state fMRI, during a median follow-up of 3.84 years. Functional brain networks were identified using independent component analysis, and a mean connectivity score was calculated for each network. Longitudinal changes in mean connectivity score were compared between treatment groups using a 2-sample

resultsFour hundred six participants had longitudinal imaging that passed quality control. The auditory-salience-language network demonstrated a significantly larger decline in the mean connectivity score in the standard treatment group relative to the intensive treatment group (

conclusionsIntensive treatment was associated with preservation of functional connectivity of the auditory-salience-language network, while mean network connectivity in other networks was not significantly different between intensive and standard therapy. A longitudinal increase in the white matter hyperintensity burden is associated with a decline in mean connectivity of the default mode network.

Indexed as

BrainHypertensionBlood PressureBrain MappingHumansMagnetic Resonance Imaging

Identifiers

PMID37105682
PMCPMC10171386
OpenAlexW4367176885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.