Evidence map›Paper›PMID 37105558›Full record

ArticleInternational journal of stem cells2023

Notch is Not Involved in Physioxia-Mediated Stem Cell Maintenance in Midbrain Neural Stem Cells.

Anne Herrmann, Anne K Meyer, Lena Braunschweig, Lisa Wagenfuehr, Franz Markert, Deborah Kolitsch, Vladimir Vukicevic, Christiane Hartmann, Marlen Siebert, Monika Ehrhart-Bornstein and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Anne HerrmannDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Anne K MeyerDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Lena BraunschweigDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Lisa WagenfuehrDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Franz MarkertDepartment of Neurology, University of Rostock, Rostock, Germany.
Deborah KolitschDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Vladimir VukicevicMolecular Endocrinology, Medical Clinic III, University Clinic Dresden, Technische Universität Dresden, Dresden, Germany.
Christiane HartmannTranslational Neurodegeneration Section Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
Marlen SiebertDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Monika Ehrhart-BornsteinMolecular Endocrinology, Medical Clinic III, University Clinic Dresden, Technische Universität Dresden, Dresden, Germany.
Andreas HermannDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Alexander StorchDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
TU Dresden · DEUniversity of Rostock · DEGerman Center for Neurodegenerative Diseases · DEUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: The physiological oxygen tension in fetal brains (∼3%, physioxia) is beneficial for the maintenance of neural stem cells (NSCs). Sensitivity to oxygen varies between NSCs from different fetal brain regions, with midbrain NSCs showing selective susceptibility. Data on Hif-1α/Notch regulatory interactions as well as our observations that Hif-1α and oxygen affect midbrain NSCs survival and proliferation prompted our investigations on involvement of Notch signalling in physioxia-dependent midbrain NSCs performance. Methods and Results: Here we found that physioxia (3% O Conclusions: Notch signalling does not influence the fate decision of midbrain NSCs cultured

Indexed as

Cell cycleHif-1αHypoxiaNeural stem cellsNotchPhysioxiaStem cell maintenance

Identifiers

PMID37105558
PMCPMC10465337
OpenAlexW4367172247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.