Evidence map›Paper›PMID 37104965›Full record

ArticlePsychoneuroendocrinology2023

Maximal telomerase activity capacity (mTAC) underlies the link between the cortisol response to stress and telomere length.

Karin de Punder, Christine Heim, Dries S Martens, Pathik D Wadhwa, Sonja Entringer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Karin de PunderCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, 10117 Berlin, Germany; Department of Psychology, Clinical Psychology-II, University of Innsbruck, Innsbruck, Austria. Electronic address: Karin.De-Punder@uibk.ac.at.
Christine HeimCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, 10117 Berlin, Germany; Center for Safe and Healthy Children, College of Health and Human Development, Pennsylvania State University, PA, USA.
Dries S MartensCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Pathik D WadhwaDepartment of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA; Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA; Department of Pediatrics, School of Medicine, University of California, Irvine, CA, USA; Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA; Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, CA, USA.
Sonja EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, 10117 Berlin, Germany; Department of Pediatrics, School of Medicine, University of California, Irvine, CA, USA; Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, CA, USA.
University of California, Irvine · USHasselt University · BEPennsylvania State University · USUniversität Innsbruck · AT

Funding

EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
NICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD087230 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HYAGRIV N SIMHAN · 2016 to 2026
$3.2M
Social Disadvantage and Fetal Programming of Newborn-Infant Telomere BiologyR01AG050455 · NIA · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI EPEL, ELISSA S., SIMHAN, HYAGRIV N · 2016 to 2020
$3.0M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NIA NIH HHS R01 AG050455NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NICHD NIH HHS UG1 HD087230
6 · The paper itself

Abstract

Exposure to various forms of stress has been associated with shorter telomere length (TL). However, the molecular underpinnings of this effect are poorly understood. Based on an understanding of the key role of the reverse transcriptase enzyme telomerase in regulating TL, and building upon our previous work in developing and validating a biomarker of the capacity of cells to express telomerase (maximal telomerase activity capacity (mTAC)), we examine here the hypotheses that mTAC is positively associated with TL and that the effect of stress on TL is mediated by individual differences in mTAC. In a proof-of-principle study of 28 healthy women and men we quantified the cortisol response to a standardized stress challenge, the Trier Social Stress Test (TSST), and we concurrently assessed peripheral blood mononuclear cell (PBMC) mTAC and TL. Our results indicated that higher mTAC levels were associated with longer TL (r = 0.50, p = .01). Moreover, mediational analysis suggested that the effect of the cortisol stress response on TL was mediated by mTAC (completely standardized β = -0.17, bootstrap CI95 %: -0.44 to -0.01). Thus, our findings support the premise that individual differences in the capacity of cells to up-regulate telomerase may represent a key mediator in the link between stress and TL.

Indexed as

TelomeraseFemaleHumansHydrocortisoneLeukocytes, MononuclearMaleTelomereHydrocortisoneTelomeraseCortisolPeripheral blood mononuclear cell (PBMC)StressTelomerase activityTelomere length

Identifiers

PMID37104965
PMCPMC10428177
OpenAlexW4366483389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.