ArticleAmerican journal of public health2023
Public Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials.
Article in American journal of public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Quasi-experimental methods for pharmacoepidemiology: difference-in-differences and synthetic control methods with case studies for vaccine evaluation.American journal of epidemiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has revealed the importance of the population-scale effects of both diseases and interventions. Vaccines have had an enormous impact, greatly reducing the suffering caused by COVID-19. Clinical trials have focused on individual-level clinical benefits, however, so the broader effects of the vaccines on preventing infection and transmission, and their overall effect at the community level, remain unclear. These questions can be addressed through alternative designs for vaccine trials, including assessing different endpoints and randomizing at the cluster instead of individual level. Although these designs exist, various factors have limited their use as preauthorization pivotal trials. They face statistical, epidemiological, and logistical limitations as well as regulatory barriers and uncertainty. Addressing these hindrances through research, communication, and policy can improve the evidence base of vaccines, their strategic deployment, and population health, both in the COVID-19 pandemic and in future infectious disease outbreaks. (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.