Evidence map›Paper›PMID 37104670›Full record

ArticleJournal of the American Chemical Society2023

Peptide Selenocysteine Substitutions Reveal Direct Substrate-Enzyme Interactions at Auxiliary Clusters in Radical

Katherine W Rush, Karsten A S Eastman, William M Kincannon, Ninian J Blackburn, Vahe Bandarian

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. The radical SAM enzyme EpeE exhibits distinct site reactivity during the biosynthesis of the RiPP natural product epipeptide.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. RadicalJournal of the American Chemical Society · 2026
    Article
  3. Diverse thioether macrocyclized peptides through a radical SAM maturase.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Ripping and stitching with copper.Nature chemical biology · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katherine W RushDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239, United States.ORCID 0000-0001-6842-9055
Karsten A S EastmanDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-2754-4222
William M KincannonDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.ORCID 0000-0003-2392-2764
Ninian J BlackburnDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239, United States.ORCID 0000-0002-9755-7838
Vahe BandarianDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.ORCID 0000-0003-2302-0277
University of Utah · USOregon Health & Science University · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
This proposal is in response to PA-20-272. It is an administrative supplement to purchase a new peptide synthesizer to support R35 GM126956R35GM126956 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI VAHE BANDARIAN · 2018 to 2026
$5.3M
Peptide Processing by Copper EnzymesR35GM136239 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Ninian J Blackburn · 2020 to 2026
$3.4M
Program for Interdisciplinary Training in CHemical BiologyT32GM122740 · NIGMS · UNIVERSITY OF UTAH · PI KAY, MICHAEL S · 2018 to 2022
$932k
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM126956NIGMS NIH HHS R35 GM136239NIGMS NIH HHS T32 GM122740
6 · The paper itself

Abstract

Radical

Indexed as

SelenocysteineMethionineModels, MolecularPeptide HydrolasesPeptidesProtein Processing, Post-TranslationalProtein Structure, TertiarySubstrate SpecificityMethioninePeptide HydrolasesPeptidesSelenocysteine

Identifiers

PMID37104670
PMCPMC10177961
OpenAlexW4367173324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.