ArticleScience (New York, N.Y.)2023
Bacterial spore germination receptors are nutrient-gated ion channels.
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 81 citations in OpenAlex.
- From dividing to dormant: embracing the full activity spectrum for environmental microorganisms.Microbiology and molecular biology reviews : MMBR · 2026Review
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- Distinctive spore architecture and developmental biology ofJournal of bacteriology · 2026Article
- Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis.Nature communications · 2026Article
- A mathematical kinetic model of memory iniScience · 2026Article
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- Structural and functional analysis of themBio · 2026Article
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- The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination.PLoS biology · 2026Article
- Exploring the lipoproteome of Parageobacillus thermoglucosidasius.Access microbiology · 2026Article
- GerAB residues predicted to interact with water based on MD simulations mediate germinosome stability inFrontiers in microbiology · 2026Article
- Early activation of bioenergetic metabolism powers bacterial spore germination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fast-growingbioRxiv : the preprint server for biology · 2025Article
- Structural and functional analysis ofMicrobiology (Reading, England) · 2025Article
- Revisiting bacterial spore germination in the presence of peptidoglycan fragments.Journal of bacteriology · 2025Article
- Resuscitation-promoting factor (Rpf) terminates dormancy among diverse soil bacteria.mSystems · 2025Article
- Article
- Article
- Germination ofJournal of bacteriology · 2025Article
- Programming Aliphatic Polyester Degradation by Engineered Bacterial Spores.Biomacromolecules · 2025Article
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9 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial spores resist antibiotics and sterilization and can remain metabolically inactive for decades, but they can rapidly germinate and resume growth in response to nutrients. Broadly conserved receptors embedded in the spore membrane detect nutrients, but how spores transduce these signals remains unclear. Here, we found that these receptors form oligomeric membrane channels. Mutations predicted to widen the channel initiated germination in the absence of nutrients, whereas those that narrow it prevented ion release and germination in response to nutrients. Expressing receptors with widened channels during vegetative growth caused loss of membrane potential and cell death, whereas the addition of germinants to cells expressing wild-type receptors triggered membrane depolarization. Therefore, germinant receptors act as nutrient-gated ion channels such that ion release initiates exit from dormancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.