Evidence map›Paper›PMID 37104562›Full record

ReviewCirculation research2023

The Lymphatic Vasculature in Cardiac Development and Ischemic Heart Disease.

Xiaolei Liu, Guillermo Oliver

Open access · greenAbstract readReview
In one paragraph

Review in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  3. HeartMap charts new territory in cardiac disease biology.Nature cardiovascular research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Xiaolei LiuDepartment of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (X.L.).
Guillermo OliverCenter for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (G.O.).ORCID 0000-0003-3984-7615
Northwestern University · USTemple University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Mitochondrial respiration as a regulator of lymphatic cell fate and therapeutic lymphangiogenesisR01HL162800 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI OLIVER, GUILLERMO C, SOSA-PINEDA, BEATRIZ · 2022 to 2025
$3.0M
Functional roles of lymphatics in organogenesis and tissue repairR01HL151388 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI OLIVER, GUILLERMO C · 2021 to 2024
$2.5M
Dissecting the functional roles of cardiac lymphatics in ischemic heart diseaseR01HL163269 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAOLEI LIU · 2023 to 2026
$1.9M
Andor Revolution XD Live Cell Imaging System with Photomanipulation LaserS10RR031680 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GELFAND, VLADIMIR I · 2011 to 2011
$437k
NCI NIH HHS P30 CA060553NCRR NIH HHS S10 RR031680NHLBI NIH HHS R01 HL151388NHLBI NIH HHS R01 HL162800NHLBI NIH HHS R01 HL163269
6 · The paper itself

Abstract

In recent years, the lymphatic system has received increasing attention due to the fast-growing number of findings about its diverse novel functional roles in health and disease. It is well documented that the lymphatic vasculature plays major roles in the maintenance of tissue-fluid balance, the immune response, and in lipid absorption. However, recent studies have identified an additional growing number of novel and sometimes unexpected functional roles of the lymphatic vasculature in normal and pathological conditions in different organs. Among those, cardiac lymphatics have been shown to play important roles in heart development, ischemic cardiac disease, and cardiac disorders. In this review, we will discuss some of those novel functional roles of cardiac lymphatics, as well as the therapeutic potential of targeting lymphatics for the treatment of cardiovascular diseases.

Indexed as

Heart DiseasesLymphatic VesselsMyocardial IschemiaHeartHumansLymphangiogenesisembryonic developmentendothelial cellsheart diseaseslymphangiogenesislymphatic vesselsparacrine communicationregeneration

Identifiers

PMID37104562
PMCPMC10154041
OpenAlexW4367173715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.