ArticleAge and ageing2023
Adverse childhood experiences and the development of multimorbidity across adulthood-a national 70-year cohort study.
Article in Age and ageing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Adverse Childhood Experiences and Life Course Adversity Related to Geriatric Syndromes: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Adverse childhood experiences and sarcopenia: a prospective study embedded in the Canadian Longitudinal Study on Aging.Age and ageing · 2026Article
- Childhood adversity and disadvantage in relation to incident disability and multimorbidity: prospective analyses of ELSA and two SHARE inception samples.Frontiers in public health · 2026Article
- Creative expressive therapy in schools to address childhood trauma: a mixed methods study of a whole school trauma-informed approach.Frontiers in health services · 2026Article
- The prevalence of potentially traumatic events in childhood and associations with mental disorders, suicide and physical health in adulthood: An Australian nationally representative cross-sectional study.The Australian and New Zealand journal of psychiatry · 2026Article
- Long-term effects of health during childhood on depressive symptoms in later life: evidence from a nationally representative survey in China.BMC public health · 2025Article
- The Mediating Effects of Chronic Diseases in the Relationship Between Adverse Childhood Experiences and Trajectories of Depressive Symptoms in Later Life: A Nationwide Longitudinal Study.Healthcare (Basel, Switzerland) · 2024Article
- Article
- The Trauma PORTAL-A Blended e-Health Intervention for Survivors of Childhood Interpersonal Trauma: An Open-Label Pilot Study.Telemedicine reports · 2024Article
- Predictors of change in poor mental health and obesity (including overweight) comorbidity in mid-adolescence: A longitudinal analysis using the millennium cohort study.Journal of multimorbidity and comorbidityArticle
- Adverse childhood experiences and mental ill-health - obesity comorbidity among British adolescents - A national cohort study.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo examine impact of adverse childhood experiences (ACE) on rates and development of multimorbidity across three decades in adulthood.
methodsSample: Participants from the 1946 National Survey of Health and Development, who attended the age 36 assessment in 1982 and follow-up assessments (ages 43, 53, 63, 69; N = 3,264, 51% males). Prospectively collected data on nine ACEs was grouped into (i) psychosocial, (ii) parental health and (iii) childhood health. For each group, we calculated cumulative ACE scores, categorised into 0, 1 and ≥2 ACEs. Multimorbidity was estimated as the total score of 18 health disorders.Serial cross-sectional linear regression was used to estimate associations between grouped ACEs and multimorbidity during follow-up. Longitudinal analysis of ACE-associated changes in multimorbidity trajectories across follow-up was estimated using linear mixed-effects modelling for ACE groups (adjusted for sex and childhood socioeconomic circumstances).
findingsAccumulation of psychosocial and childhood health ACEs were associated with progressively higher multimorbidity scores throughout follow-up. For example, those with ≥2 psychosocial ACEs experienced 0.20(95% CI 0.07, 0.34) more disorders at age 36 than those with none, rising to 0.61(0.18, 1.04) disorders at age 69.All three grouped ACEs were associated with greater rates of accumulation and higher multimorbidity trajectories across adulthood. For example, individuals with ≥2 psychosocial ACEs developed 0.13(-0.09, 0.34) more disorders between ages 36 and 43, 0.29(0.06, 0.52) disorders between ages 53 and 63, and 0.30(0.09, 0.52) disorders between ages 63 and 69 compared with no psychosocial ACEs. INTERPRETATIONS: ACEs are associated with widening inequalities in multimorbidity development in adulthood and early old age. Public health policies should aim to reduce these disparities through individual and population-level interventions.
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