Evidence map›Paper›PMID 37104214›Full record

ArticleToxins2023

Proton-Pump Inhibitors and Serum Concentrations of Uremic Toxins in Patients with Chronic Kidney Disease.

Carolla El Chamieh, Islam Amine Larabi, Solène M Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Céline Lange and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Carolla El ChamiehCentre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France.ORCID 0000-0003-2536-556X
Islam Amine LarabiDepartment of Pharmacology and Toxicology, Raymond Poincaré Hospital, AP-HP, 92380 Garches, France.ORCID 0000-0002-9015-5342
Solène M LavillePharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens-Picardie University Medical Center, 80054 Amiens, France.ORCID 0000-0002-0214-5567
Christian JacquelinetCentre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France.ORCID 0000-0002-5904-7570
Christian CombeService de Néphrologie Transplantation Dialyse Aphérèse, Centre Hospitalier Universitaire de Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-0360-573X
Denis FouqueNephrology Department, Centre Hospitalier Lyon Sud, Université de Lyon, Carmen, 69495 Pierre-Bénite, France.
Maurice LavilleUniversité de Lyon, CarMeN INSERM 1060, 69008 Lyon, France.
Luc FrimatNephrology Department, CHRU de Nancy, 54000 Vandoeuvre-lès-Nancy, France.
Roberto Pecoits-FilhoArbor Research Collaborative for Health, Ann Arbor, MI 48108, USA.
Céline LangeCentre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France.
Bénédicte StengelCentre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France.
Natalia Alencar De PinhoCentre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France.
Jean-Claude AlvarezDepartment of Pharmacology and Toxicology, Raymond Poincaré Hospital, AP-HP, 92380 Garches, France.ORCID 0000-0001-5344-9475
Ziad A MassyCentre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France.
Sophie LiabeufPharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens-Picardie University Medical Center, 80054 Amiens, France.ORCID 0000-0001-5384-9006
Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) Study Group
Inserm · FRCentre Hospitalier Universitaire Amiens-Picardie · FRUniversité Claude Bernard Lyon 1 · FRInterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est · FRPontifícia Universidade Católica do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Use of proton-pump inhibitors (PPIs) is common in patients with chronic kidney disease (CKD). PPIs and many uremic toxins (UTs) are eliminated by the kidney's tubular organic anion transporter system. In a cross-sectional study, we sought to evaluate the association between PPI prescription and serum concentrations of various UTs. We studied a randomly selected sub-group of participants in the CKD-REIN cohort (adult patients with a confirmed diagnosis of CKD and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m

Indexed as

Renal Insufficiency, ChronicUremiaAdultAgedCross-Sectional StudiesHumansIndicanProton Pump InhibitorsUremic ToxinsIndicanProton Pump InhibitorsUremic Toxinschronic kidney diseaseindoxyl sulfateproton-pump inhibitoruremic toxins

Identifiers

PMID37104214
PMCPMC10143607
OpenAlexW4362699320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.