Evidence map›Paper›PMID 37104177›Full record

ArticleToxins2023

High-Throughput IgG Epitope Mapping of Tetanus Neurotoxin: Implications for Immunotherapy and Vaccine Design.

Salvatore G De-Simone, Paloma Napoleão-Pêgo, Guilherme C Lechuga, João P R S Carvalho, Larissa R Gomes, Sergian V Cardozo, Carlos M Morel, David W Provance, Flavio R da Silva

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Immunodominant IgM Epitopes of theInternational journal of molecular sciences · 2026
    Article
  3. IgM and IgG Epitope Mapping of the Porin Outer Membrane Protein-2a fromInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Dynamics of IgM and IgA Antibody Response Profile AgainstInternational journal of molecular sciences · 2025
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Salvatore G De-SimoneCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-2172-656X
Paloma Napoleão-PêgoCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.
Guilherme C LechugaCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.
João P R S CarvalhoCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.
Larissa R GomesCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-7194-0858
Sergian V CardozoDepartment of Health, Graduate Program in Translational Biomedicine (BIOTRANS), University of Grande Rio (UNIGRANRIO), Caxias 25071-202, RJ, Brazil.
Carlos M MorelCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0003-2752-0009
David W ProvanceCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-9824-0672
Flavio R da SilvaCenter for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal Fluminense · BRUniversidade Unigranrio · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetanus is an acute, fatal disease caused by exotoxins released from

Indexed as

Epitopes, B-LymphocyteTetanusChildEpitope MappingHumansImmunoglobulin GMetalloendopeptidasesPeptidesTetanus ToxinVaccinationEpitopes, B-LymphocyteImmunoglobulin GMetalloendopeptidasesPeptidestetanospasminTetanus ToxinB-cell linear epitopesimmunological diagnosticpeptide ELISAtetanus neurotoxin

Identifiers

PMID37104177
PMCPMC10146279
OpenAlexW4360848033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.