Evidence map›Paper›PMID 37103671›Full record

ArticleEJNMMI research2023

Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma.

Kevin P Labadie, Adrienne L Lehnert, Aimee L Kenoyer, Donald K Hamlin, Andrew D Ludwig, Alan F Utria, Sara K Daniel, Tara N Mihailovic, Alexander Prossnitz, Johnnie J Orozco and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Glypican-3-targeted immunoPET imaging of hepatocellular carcinoma: a translational study.European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Kevin P LabadieDepartment of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA.
Adrienne L LehnertDepartment of Radiology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Aimee L KenoyerClinical Research Division, Fred Hutch Cancer Research Center, 100 Fairview Ave N, Seattle, WA, 98109, USA.
Donald K HamlinDepartment of Radiation Oncology, University of Washington School of Medicine, 616 NE Northlake Pl., Seattle, WA, 98105, USA.
Andrew D LudwigDepartment of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA.
Alan F UtriaDepartment of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA.
Sara K DanielDepartment of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA.
Tara N MihailovicDepartment of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA.
Alexander ProssnitzDepartment of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA, 98195, USA.
Johnnie J OrozcoClinical Research Division, Fred Hutch Cancer Research Center, 100 Fairview Ave N, Seattle, WA, 98109, USA.
Yawen LiDepartment of Radiation Oncology, University of Washington School of Medicine, 616 NE Northlake Pl., Seattle, WA, 98105, USA.
D Scott WilburDepartment of Radiation Oncology, University of Washington School of Medicine, 616 NE Northlake Pl., Seattle, WA, 98105, USA.
Robert S MiyaokaDepartment of Radiology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
James O ParkDepartment of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA. jopark@uw.edu.ORCID http://orcid.org/0000-0001-6939-1255
University of Washington · USFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Small Animal CT SystemS10OD017980 · OD · UNIVERSITY OF WASHINGTON · PI MIYAOKA, ROBERT S · 2014 to 2014
$547k
Small Animal PET SystemS10RR024689 · NCRR · UNIVERSITY OF WASHINGTON · PI MIYAOKA, ROBERT S · 2008 to 2008
$500k
Caliper Life Sciences IVIS Lumina II imaging systemS10OD010652 · OD · UNIVERSITY OF WASHINGTON · PI COOKSON, BRAD T · 2012 to 2012
$161k
NCI NIH HHS P30 CA015704NCRR NIH HHS S10 RR024689NIH HHS 1S10OD010652-01NIH HHS 1S10OD017980-0NIH HHS P30 CA015704NIH HHS S10 OD010652NIH HHS S10 OD017980NIH HHS S10RR024689-01
6 · The paper itself

Abstract

backgroundEarly intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to EIR and results in missed treatment opportunities. In addition, novel modalities are needed to identify targets amenable for targeted molecular therapy. In this study, we evaluated a zirconium-89 radiolabeled glypican-3 (GPC3) targeting antibody conjugate (

resultsIn tumor-bearing mice,

conclusions

Indexed as

Glypican-3 (GPC3)Hepatocellular carcinoma (HCC)Immuno-positron emission tomography (PET)Targeted molecular therapy

Identifiers

PMID37103671
PMCPMC10140215
OpenAlexW4367174500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.