Evidence map›Paper›PMID 37103656›Full record

ArticleInternational urology and nephrology2023

Association of malnutrition with all-cause and cardiovascular mortality in patients with mild to severe chronic kidney disease undergoing coronary angiography: a large multicenter longitudinal study.

Fei Gao, Zhidong Huang, JingJing Liang, Yu Kang, Yihang Ling, Yibo He, Jiahui Chen, Daqing Hong, Zewei Zhang, Shanshan Xu and 6 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05050877 (Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention - Cardiorenal ImprovemeNt Registry II), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05050877 completednot on this map

Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention - Cardiorenal ImprovemeNt Registry II

TypeobservationalSponsorGuangdong Provincial People's HospitalRan2000 to 2020Enrolled184,855ConditionsCardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Fei Gao *Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Zhidong Huang *Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
JingJing Liang *Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.
Yu Kang *Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Yihang LingDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Yibo HeDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Jiahui ChenDepartment of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Daqing HongDepartment of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Zewei ZhangDepartment of Public Health, Guangdong Medical University, Dongguan, China.
Shanshan XuThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Amanda WangThe George Institute for Global Health, UNSW, Sydney, Australia.
Xiaoming YanDepartment of Information Technology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Jin LiuDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Yong LiuDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Shiqun ChenDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. shiqunchen@126.com.ORCID http://orcid.org/0000-0002-2847-019X
Jiyan ChenDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. chenjiyandr@126.com.
Guangdong Academy of Medical Sciences · CNGuangdong Pharmaceutical University · CNCapital Medical University · CNGuangdong Medical College · CNShantou University · CNSouthern Medical University · CNThe First People's Hospital of Shunde · CNUniversity of Electronic Science and Technology of China · CNUNSW Sydney · AU

Funding

Beijing Lisheng Cardiovascular Health Foundation Beijing Lisheng Cardiovascular Health FoundationGuangdong Provincial People's Hospital DFJH201919Guangdong Provincial science and technology project 2020B1111170011Guangdong Provincial science and technology project KJ022021049National Science Foundation of China 81670339National Science Foundation of China 81970311
6 · The paper itself

Abstract

purposeEvidence on the prognostic impact of malnutrition was focused on patients with advanced kidney disease. The relationships between malnutrition and all-cause and cardiovascular mortality in patients with different severity of chronic kidney disease (CKD) have not been adequately addressed. We aimed to reveal the prevalence of malnutrition and its prognostic value in patients with different severity of CKD undergoing coronary angiography (CAG).

methodsThis was a multicenter, longitudinal, and retrospective cohort study of 12,652 patients with non-dialysis dependent CKD (defined as estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m

resultsDuring a median follow-up of 5.5 years (interquartile range: 3.2 to 8.6 years), 3801 patients (30.0%) died, and 2150 (17.0%) definitely died of cardiovascular disease. After controlling for confounders, patients had higher all-cause mortality (mild, moderate, and severe vs. absent: HR 1.27, 95 CI % [1.17-1.39]; HR 1.54, 95 CI % [1.39-1.71]; HR 2.22, 95 CI % [1.78-2.77], respectively; P for trend < 0.001) and cardiovascular mortality (mild, moderate and severe vs. absent: HR 1.35, 95 CI % [1.21-1.52]; HR 1.67, 95 CI % [1.45-1.92]; HR 2.10, 95 CI % [1.55-2.85], respectively; P for trend < 0.001) with the severity of malnutrition. In further stratified analysis, a similar prognostic impact of malnutrition was observed in patients with mild to moderate CKD, while mild malnutrition did not seem to have a consistent effect on severe CKD patients.

conclusionMalnutrition is common among patients with mild to severe CKD undergoing CAG and is strongly associated with increased risk of all-cause and cardiovascular mortality. Malnutrition seems to have a modestly stronger impact on mortality in patients with mild to moderate CKD. This study was registered at Clinicaltrials.gov as NCT05050877.

Indexed as

Cardiovascular DiseasesMalnutritionRenal Insufficiency, ChronicCoronary AngiographyHumansLongitudinal StudiesRetrospective StudiesRisk FactorsAll-cause mortalityCardiovascular mortalityChronic kidney diseaseMalnutritionPrevalenceThe CONUT score

Identifiers

PMID37103656
OpenAlexW4367175037

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.