Evidence map›Paper›PMID 37103598›Full record

ReviewBreast cancer research and treatment2023

Advances in the prevention and treatment of breast cancer-related lymphedema.

Paula M C Donahue, Adrien MacKenzie, Aleksandra Filipovic, Louise Koelmeyer

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 4 pooled it
28.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06591871 nacompletednot on this map

Effect of Self-management Educational Program on Women's Self-care and Quality of Life Post Mastectomy Lymphedema

TypeinterventionalSponsorAssiut UniversityRan2023 to 2024Enrolled40ConditionsPost Mastectomy LymphedemaArmsSelf-management educational program for post mastectomy lymphedema women
NCT07154771 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Development and Usability Evaluation of an Arm Circumference Measurement Tool For Patients Undergoing Breast Surgery

TypeinterventionalSponsorSaglik Bilimleri Universitesi Gulhane Tip FakultesiRan2025 to 2025Enrolled35ConditionsBreast Surgery, Breast Cancer, LymphedemaArmsFirst with the arm circumference measurement tool, then with the traditional tape measure, First with the traditional tape measure , then with the arm circumference measurement tool
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Intermittent pneumatic compression devices for the prevention and treatment of breast cancer-related lymphedema-a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  4. Pooled it
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  6. The effects of early rehabilitation on physical and psychosocial functions after breast cancer surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  7. Trial
  8. Impact of text reminders on pneumatic compression device (PCD) compliance in patients with breast cancer-related lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
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  10. Observational
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  13. Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Paula M C DonahuePhysical Medicine and Rehabilitation, Vanderbilt University Medical Center, 2201 21St Children's Way, Suite 1218, Nashville, TN, 37212, USA. paula.m.donahue@vumc.org.ORCID http://orcid.org/0000-0003-4656-6539
Adrien MacKenzieOsher Center for Integrative Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Aleksandra FilipovicPureTech Health, London, UK.
Louise KoelmeyerFaculty of Medicine, Health, and Human Sciences, Australian Lymphoedema Education, Research, and Treatment (ALERT), Macquarie University, Sydney, Australia.
Vanderbilt University Medical Center · USMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBreast cancer-related lymphedema (BCRL) represents a lifelong risk for breast cancer survivors and once acquired becomes a lifelong burden. This review summarizes current BCRL prevention and treatment strategies.

findingsRisk factors for BCRL have been extensively studied and their identification has affected breast cancer treatment practice, with sentinel lymph node removal now standard of care for patients with early stage breast cancer without sentinel lymph node metastases. Early surveillance and timely management aim to reduce BCRL incidence and progression, and are further facilitated by patient education, which many breast cancer survivors report not having adequately received. Surgical approaches to BCRL prevention include axillary reverse mapping, lymphatic microsurgical preventative healing (LYMPHA) and Simplified LYMPHA (SLYMPHA). Complete decongestive therapy (CDT) remains the standard of care for patients with BCRL. Among CDT components, facilitating manual lymphatic drainage (MLD) using indocyanine green fluorescence lymphography has been proposed. Intermittent pneumatic compression, nonpneumatic active compression devices, and low-level laser therapy appear promising in lymphedema management. Reconstructive microsurgical techniques such as lymphovenous anastomosis and vascular lymph node transfer are growing surgical considerations for patients as well as liposuction-based procedures for addressing fatty fibrosis formation from chronic lymphedema. Long-term self-management adherence remains problematic, and lack of diagnosis and measurement consensus precludes a comparison of outcomes. Currently, no pharmacological approaches have proven successful.

conclusionProgress in prevention and treatment of BCRL continues, requiring advances in early diagnosis, patient education, expert consensus and novel treatments designed for lymphatic rehabilitation following insults.

Indexed as

Breast Cancer LymphedemaBreast NeoplasmsLymphedemaFemaleHumansLymph Node ExcisionManual Lymphatic DrainageRisk FactorsBreast cancerBreast cancer lymphedemaIndocyanine greenLymphedemaManual lymphatic drainageOptical imaging

Identifiers

PMID37103598
PMCPMC10224871
OpenAlexW4367175016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.