Evidence map›Paper›PMID 37103356›Full record

ReviewMarine drugs2023

Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides.

Jiameng Liu, Mengli Zhang, Zhenkuai Huang, Jiaqi Fang, Zhongyuan Wang, Chengxu Zhou, Xiaoting Qiu

Abstract readReview
In one paragraph

Review in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Complete Genomes ofMicroorganisms · 2025
    Article
  5. Article
  6. Review
  7. Biosynthesis of guanidine-containing natural products in cyanobacteria.Journal of industrial microbiology & biotechnology · 2024
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiameng LiuMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
Mengli ZhangMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
Zhenkuai HuangMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
Jiaqi FangMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
Zhongyuan WangMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
Chengxu ZhouMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
Xiaoting QiuMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.

Funding

National key research and development program of China 2018YFA0903004National Natural Science Foundation of China 31400683Natural Science Foundation of Zhejiang Province LQ14C050001Subject Project of Ningbo University XYL20019
6 · The paper itself

Abstract

Aeruginosins, a family of nonribosomal linear tetrapeptides discovered from cyanobacteria and sponges, exhibit in vitro inhibitory activity on various types of serine proteases. This family is characterized by the existence of the 2-carboxy-6-hydroxy-octahydroindole (Choi) moiety occupied at the central position of the tetrapeptide. Aeruginosins have attracted much attention due to their special structures and unique bioactivities. Although many studies on aeruginosins have been published, there has not yet been a comprehensive review that summarizes the diverse research ranging from biogenesis, structural characterization and biosynthesis to bioactivity. In this review, we provide an overview of the source, chemical structure as well as spectrum of bioactivities of aeruginosins. Furthermore, possible opportunities for future research and development of aeruginosins were discussed.

Indexed as

Biological ProductsCyanobacteriaPeptidesBiological ProductsPeptidesaeruginosinsbiogenesisChoinonribosomal polypeptide synthesisserine protease inhibitory activitystructural diversity

Identifiers

PMID37103356
PMCPMC10143770

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.